抗心磷脂抗体持续存在在系统性红斑狼疮中的临床重要性。
Clinical importance of persistence of anticardiolipin antibodies in systemic lupus erythematosus.
作者信息
Ishii Y, Nagasawa K, Mayumi T, Niho Y
机构信息
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
出版信息
Ann Rheum Dis. 1990 Jun;49(6):387-90. doi: 10.1136/ard.49.6.387.
The clinical importance of IgG anticardiolipin antibodies was investigated in systemic lupus erythematosus (SLE). IgG anticardiolipin antibodies were found in 69 of 155 (44.5%) patients with SLE. Serial measurements of IgG anticardiolipin antibodies allowed the patients to be classified into two groups: group A, persistently positive for IgG anticardiolipin antibodies; group B, positive only in active phases. The IgG anticardiolipin antibody titre in group A was significantly higher than in group B. The incidence of thromboses, spontaneous abortions, and lupus anticoagulant in group A was significantly higher than in group B (p less than 0.05). By contrast, the incidence of renal diseases and anti-dsDNA antibodies in group B was significantly higher than in group A (p less than 0.05). This study showed that group A formed a separate subgroup of patients with SLE who had a high risk of thromboses and spontaneous abortions despite having milder disease activity.
在系统性红斑狼疮（SLE）中研究了IgG抗心磷脂抗体的临床重要性。155例SLE患者中有69例（44.5%）检测到IgG抗心磷脂抗体。对IgG抗心磷脂抗体进行连续测量可将患者分为两组：A组，IgG抗心磷脂抗体持续呈阳性；B组，仅在活动期呈阳性。A组的IgG抗心磷脂抗体滴度显著高于B组。A组中血栓形成、自然流产和狼疮抗凝物的发生率显著高于B组（p<0.05）。相比之下，B组中肾脏疾病和抗双链DNA抗体的发生率显著高于A组（p<0.05）。本研究表明，A组构成了SLE患者中的一个独立亚组，尽管疾病活动较轻，但有较高的血栓形成和自然流产风险。
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