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1
Need for Specialized Therapeutic Stem Cells Banks Equipped with Tumor Regression Enzymes and Anti-Tumor Genes.需要配备肿瘤消退酶和抗肿瘤基因的专业治疗性干细胞库。
J Biomed Allied Res. 2020 Jun;2(1). doi: 10.37191/mapsci-2582-4937-2(1)-013. Epub 2020 Mar 16.
2
Fundamental Principles of Stem Cell Banking.干细胞库的基本原理。
Adv Exp Med Biol. 2016;951:31-45. doi: 10.1007/978-3-319-45457-3_3.
3
Stem cell research and regenerative medicine at King Abdullah International Medical Research Center.阿卜杜拉国王国际医学研究中心的干细胞研究与再生医学
Stem Cells Dev. 2014 Dec;23 Suppl 1:12-6. doi: 10.1089/scd.2014.0303.
4
Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas.二氢嘧啶脱氢酶是间充质干细胞介导的胞嘧啶脱氨酶基因和5-氟胞嘧啶前药疗法治疗复发性胶质瘤的预后标志物。
Theranostics. 2016 Jun 17;6(10):1477-90. doi: 10.7150/thno.14158. eCollection 2016.
5
Targeted inhibition of osteosarcoma tumor growth by bone marrow-derived mesenchymal stem cells expressing cytosine deaminase/5-fluorocytosine in tumor-bearing mice.在荷瘤小鼠中，表达胞嘧啶脱氨酶/5-氟胞嘧啶的骨髓间充质干细胞对骨肉瘤肿瘤生长的靶向抑制作用。
J Gene Med. 2015 Mar-May;17(3-5):87-99. doi: 10.1002/jgm.2826.
6
Synergistic effects of genetically engineered stem cells expressing cytosine deaminase and interferon-β via their tumor tropism to selectively target human hepatocarcinoma cells.通过表达胞嘧啶脱氨酶和干扰素-β的基因工程干细胞对肿瘤的趋向性的协同作用，选择性地靶向人肝癌细胞。
Cancer Gene Ther. 2012 Sep;19(9):644-51. doi: 10.1038/cgt.2012.45. Epub 2012 Jul 13.
7
Cytosine deaminase-expressing human neural stem cells inhibit tumor growth in prostate cancer-bearing mice.表达胞嘧啶脱氨酶的人神经干细胞抑制荷前列腺癌小鼠肿瘤生长。
Cancer Lett. 2013 Jul 10;335(1):58-65. doi: 10.1016/j.canlet.2013.01.048. Epub 2013 Feb 4.
8
Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma.表达酵母胞嘧啶脱氨酶::尿嘧啶磷酸核糖基转移酶的人脂肪组织来源间充质干细胞抑制大鼠脑内胶质母细胞瘤。
Int J Cancer. 2012 May 15;130(10):2455-63. doi: 10.1002/ijc.26278. Epub 2011 Aug 24.
9
Stem-Cell Therapy Advances in China.中国的干细胞疗法取得进展。
Hum Gene Ther. 2018 Feb;29(2):188-196. doi: 10.1089/hum.2017.224.
10
Antitumor effects of genetically engineered stem cells expressing yeast cytosine deaminase in lung cancer brain metastases via their tumor-tropic properties.通过具有肿瘤趋向性的基因工程表达酵母胞嘧啶脱氨酶的干细胞对肺癌脑转移的抗肿瘤作用。
Oncol Rep. 2012 Jun;27(6):1823-8. doi: 10.3892/or.2012.1721. Epub 2012 Mar 13.

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Role of CD9 Sensing, AI, and Exosomes in Cellular Communication of Cancer.CD9 传感、人工智能和外泌体在癌症细胞通讯中的作用。
Int J Stem Cell Res Ther. 2023;10(1). doi: 10.23937/2469-570X/1410079. Epub 2023 May 20.
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Protein Expression Profiles in Exosomes of Bovine Mammary Epithelial Cell Line MAC-T Infected with Staphylococcus aureus.牛乳腺上皮细胞系 MAC-T 感染金黄色葡萄球菌后外泌体中的蛋白质表达谱。
Appl Environ Microbiol. 2023 Apr 26;89(4):e0174322. doi: 10.1128/aem.01743-22. Epub 2023 Mar 20.
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The future of bioorthogonal-chemistry for targeting of exosomes in precision medicine.生物正交化学在精准医学中用于靶向外泌体的未来。
Oncotarget. 2022 Dec 6;13:1303-1304. doi: 10.18632/oncotarget.28323.
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Different Sourced Extracellular Vesicles and Their Potential Applications in Clinical Treatments.不同来源的细胞外囊泡及其在临床治疗中的潜在应用。
Cells. 2022 Jun 21;11(13):1989. doi: 10.3390/cells11131989.
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Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications.用于医疗应用的临床级细胞外囊泡的分离和纯化方法。
Cells. 2022 Jan 6;11(2):186. doi: 10.3390/cells11020186.
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Cytidine deamination-induced perpetual immunity to SAR-CoV-2 infection is a potential new therapeutic target.胞苷脱氨酶诱导对 SARS-CoV-2 感染的永久免疫是一个潜在的新治疗靶点。
Int J Med Sci. 2021 Oct 15;18(16):3788-3793. doi: 10.7150/ijms.61779. eCollection 2021.
7
Diagnostic and Therapeutic Potential of Extracellular Vesicles.细胞外囊泡的诊断和治疗潜力。
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211041203. doi: 10.1177/15330338211041203.
8
Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells.热休克蛋白20促进诱导多能干细胞中依赖沉默调节蛋白1的细胞增殖。
World J Stem Cells. 2021 Jun 26;13(6):659-669. doi: 10.4252/wjsc.v13.i6.659.
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Advances in innovative exosome-technology for real time monitoring of viable drugs in clinical translation, prognosis and treatment response.用于临床转化、预后和治疗反应中活性药物实时监测的创新外泌体技术进展。
Oncotarget. 2021 May 25;12(11):1029-1031. doi: 10.18632/oncotarget.27927.
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Exploring the utility of extracellular vesicles in ameliorating viral infection-associated inflammation, cytokine storm and tissue damage.探索细胞外囊泡在改善病毒感染相关炎症、细胞因子风暴和组织损伤方面的效用。
Transl Oncol. 2021 Jul;14(7):101095. doi: 10.1016/j.tranon.2021.101095. Epub 2021 Apr 19.

本文引用的文献

1
Stem cell-derived extracellular vesicles: role in oncogenic processes, bioengineering potential, and technical challenges.干细胞衍生的细胞外囊泡：在致癌过程中的作用、生物工程潜力和技术挑战。
Stem Cell Res Ther. 2019 Nov 26;10(1):347. doi: 10.1186/s13287-019-1468-6.
2
Emerging role of stem cell-derived extracellular microRNAs in age-associated human diseases and in different therapies of longevity.干细胞衍生的细胞外 microRNAs 在与年龄相关的人类疾病和不同的长寿疗法中的新兴作用。
Ageing Res Rev. 2020 Jan;57:100979. doi: 10.1016/j.arr.2019.100979. Epub 2019 Nov 5.
3
An emerging role of CD9 in stemness and chemoresistance.CD9在干性和化疗耐药性方面的新作用。
Oncotarget. 2019 Jun 18;10(40):4000-4001. doi: 10.18632/oncotarget.27021.
4
Mesenchymal stem cells confer chemoresistance in breast cancer via a CD9 dependent mechanism.间充质干细胞通过一种依赖CD9的机制赋予乳腺癌化疗耐药性。
Oncotarget. 2019 May 28;10(37):3435-3450. doi: 10.18632/oncotarget.26952.
5
Mesenchymal Stromal Cell Homing: Mechanisms and Strategies for Improvement.间充质基质细胞归巢：改善机制与策略
iScience. 2019 May 31;15:421-438. doi: 10.1016/j.isci.2019.05.004. Epub 2019 May 9.
6
Efficacies of Stem Cell Therapies for Functional Improvement of the Cell in Patients with Diabetes: A Systematic Review of Controlled Clinical Trials.干细胞疗法对糖尿病患者细胞功能改善的疗效：对照临床试验的系统评价
Int J Stem Cells. 2019 Jul 31;12(2):195-205. doi: 10.15283/ijsc18076.
7
The new kid on the block: suicide gene therapy to modulate cancer immunosurveillance for children with high-risk malignant brain tumors.新成员：自杀基因疗法调节高危恶性脑肿瘤患儿的癌症免疫监视
Neuro Oncol. 2019 Mar 18;21(4):419-420. doi: 10.1093/neuonc/noz026.
8
Exosomes Derived from Human Induced Pluripotent Stem Cells-Endothelia Cells Promotes Postnatal Angiogenesis in Mice Bearing Ischemic Limbs.人诱导多能干细胞来源的外泌体-内皮细胞促进缺血肢体小鼠的出生后血管生成。
Int J Biol Sci. 2019 Jan 1;15(1):158-168. doi: 10.7150/ijbs.28392. eCollection 2019.
9
Cancer statistics, 2019.癌症统计数据，2019 年。
CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8.
10
Prodrug suicide gene therapy for cancer targeted intracellular by mesenchymal stem cell exosomes.介体型间充质干细胞外泌体靶向的前药自杀基因疗法治疗癌症。
Int J Cancer. 2019 Feb 15;144(4):897-908. doi: 10.1002/ijc.31792. Epub 2018 Sep 27.

需要配备肿瘤消退酶和抗肿瘤基因的专业治疗性干细胞库。

Need for Specialized Therapeutic Stem Cells Banks Equipped with Tumor Regression Enzymes and Anti-Tumor Genes.

作者信息

Ullah Mujib

机构信息

Interventional Regenerative Medicine and Imaging Lab, Department of Radiology, School of Medicine, Stanford University, California, USA.

出版信息

J Biomed Allied Res. 2020 Jun;2(1). doi: 10.37191/mapsci-2582-4937-2(1)-013. Epub 2020 Mar 16.

DOI:10.37191/mapsci-2582-4937-2(1)-013
PMID:33554055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7861576/
Abstract

Stem cells are currently being used in many clinical trials for regenerative purposes. These are promising results for stem cells in the treatment of several diseases, including cancer. Nevertheless, there are still many variables which should be addressed before the application of stem cells for cancer treatment. One approach should be to establish well-characterized therapeutic stem cell banks to minimize the variation in results from different clinical trials and facilitate their effective use in basic and translational research.

摘要

目前，干细胞正被用于许多旨在实现再生目的的临床试验中。这些结果表明干细胞在治疗包括癌症在内的多种疾病方面颇具前景。然而，在将干细胞应用于癌症治疗之前，仍有许多变量需要解决。一种方法是建立特征明确的治疗性干细胞库，以尽量减少不同临床试验结果的差异，并促进其在基础研究和转化研究中的有效应用。