National Engineering Research Center of Seafood, Liaoning Provincial Aquatic Products Deep Processing Technology Research Center, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Department of Agricultural and Biosystems Engineering, Iowa State University, Ames, IA 50011, USA.
Mar Drugs. 2021 Feb 5;19(2):92. doi: 10.3390/md19020092.
Fucoxanthin (FX), a natural carotenoid found in seaweed with multiple functional activities, is unstable with a poor water solubility that limits its utilization. This study aimed to improve FX's stability and bioavailability via the nano-encapsulation of FX in polyvinylpyrrolidone (PVP)-coated FX@PVP nanoparticles (NPs). The FX@PVP NPs were evaluated in terms of their morphology, stability, encapsulation efficiency (EE), loading capacity (LC), and in vitro release to optimize the encapsulation parameters, and a 1:8 FX:PVP ratio was found to perform the best with the highest EE (85.50 ± 0.19%) and LC (10.68 ± 0.15%) and improved FX stability. In addition, the FX@PVP NPs were shown to effectively deliver FX into Caco-2 cancer cells, and the accumulation of FX in these cancer cells showed pro-oxidative activities to ameliorate HO-induced damage and cell death. The FX@PVP NPs could potentially become a new therapeutical approach for targeted cancer treatment.
岩藻黄质（FX）是一种天然类胡萝卜素，存在于海藻中，具有多种功能活性，但由于其不稳定性和较差的水溶性，限制了其应用。本研究旨在通过将 FX 纳米封装在聚乙烯吡咯烷酮（PVP）涂层的 FX@PVP 纳米颗粒（NPs）中，来提高 FX 的稳定性和生物利用度。对 FX@PVP NPs 的形态、稳定性、包封效率（EE）、载药量（LC）和体外释放进行了评估，以优化包封参数，发现 FX:PVP 比例为 1:8 时效果最佳，EE（85.50±0.19%）和 LC（10.68±0.15%）最高，且 FX 稳定性得到提高。此外，FX@PVP NPs 能够有效地将 FX 递送至 Caco-2 癌细胞，并且 FX 在这些癌细胞中的积累表现出促氧化活性，从而改善 HO 诱导的损伤和细胞死亡。FX@PVP NPs 可能成为靶向癌症治疗的一种新的治疗方法。
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