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基于图卷积网络的新型冠状病毒肺炎诊断

Diagnosis of COVID-19 Pneumonia Based on Graph Convolutional Network.

作者信息

Liang Xiaoling, Zhang Yuexin, Wang Jiahong, Ye Qing, Liu Yanhong, Tong Jinwu

机构信息

Department of Marine Engineering, Dalian Maritime University, Dalian, China.

Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.

出版信息

Front Med (Lausanne). 2021 Jan 21;7:612962. doi: 10.3389/fmed.2020.612962. eCollection 2020.

Abstract

A three-dimensional (3D) deep learning method is proposed, which enables the rapid diagnosis of coronavirus disease 2019 (COVID-19) and thus significantly reduces the burden on radiologists and physicians. Inspired by the fact that the current chest computed tomography (CT) datasets are diversified in equipment types, we propose a COVID-19 graph in a graph convolutional network (GCN) to incorporate multiple datasets that differentiate the COVID-19 infected cases from normal controls. Specifically, we first apply a 3D convolutional neural network (3D-CNN) to extract image features from the initial 3D-CT images. In this part, a transfer learning method is proposed to improve the performance, which uses the task of predicting equipment type to initialize the parameters of the 3D-CNN structure. Second, we design a COVID-19 graph in GCN based on the extracted features. The graph divides all samples into several clusters, and samples with the same equipment type compose a cluster. Then we establish edge connections between samples in the same cluster. To compute accurate edge weights, we propose to combine the correlation distance of the extracted features and the score differences of subjects from the 3D-CNN structure. Lastly, by inputting the COVID-19 graph into GCN, we obtain the final diagnosis results. In experiments, the dataset contains 399 COVID-19 infected cases, and 400 normal controls from six equipment types. Experimental results show that the accuracy, sensitivity, and specificity of our method reach 98.5%, 99.9%, and 97%, respectively.

摘要

提出了一种三维(3D)深度学习方法,该方法能够快速诊断2019冠状病毒病(COVID-19),从而显著减轻放射科医生和内科医生的负担。受当前胸部计算机断层扫描(CT)数据集设备类型多样这一事实的启发,我们在图卷积网络(GCN)中提出了一种COVID-19图,以整合多个区分COVID-19感染病例与正常对照的数据集。具体而言,我们首先应用三维卷积神经网络(3D-CNN)从初始三维CT图像中提取图像特征。在这一部分,提出了一种迁移学习方法来提高性能,该方法利用预测设备类型的任务来初始化3D-CNN结构的参数。其次,我们基于提取的特征在GCN中设计了一个COVID-19图。该图将所有样本划分为几个簇,具有相同设备类型的样本组成一个簇。然后我们在同一簇中的样本之间建立边连接。为了计算准确的边权重,我们建议将提取特征的相关距离与3D-CNN结构中受试者的得分差异相结合。最后,通过将COVID-19图输入GCN,我们得到最终的诊断结果。在实验中,数据集包含来自六种设备类型的399例COVID-19感染病例和400例正常对照。实验结果表明,我们方法的准确率、灵敏度和特异性分别达到98.5%、99.9%和97%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc87/7875085/5ea86cab973b/fmed-07-612962-g0001.jpg

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