Degen Martin, Scherberich Arnaud, Tucker Richard P
Laboratory for Oral Molecular Biology, Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland.
Tissue Engineering Laboratory, Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Front Immunol. 2021 Feb 2;11:623305. doi: 10.3389/fimmu.2020.623305. eCollection 2020.
Of the four tenascins found in bony fish and tetrapods, tenascin-W is the least understood. It was first discovered in the zebrafish and later in mouse, where it was mistakenly named tenascin-N. Tenascin-W is expressed primarily in developing and mature bone, in a subset of stem cell niches, and in the stroma of many solid tumors. Phylogenetic studies show that it is the most recent tenascin to evolve, appearing first in bony fishes. Its expression in bone and the timing of its evolutionary appearance should direct future studies to its role in bone formation, in stem cell niches, and in the treatment and detection of cancer.
在硬骨鱼和四足动物中发现的四种腱生蛋白中，腱生蛋白-W是了解最少的。它最初在斑马鱼中被发现，后来在小鼠中被发现，在小鼠中它被错误地命名为腱生蛋白-N。腱生蛋白-W主要在发育中的和成熟的骨骼、干细胞龛的一个子集中以及许多实体瘤的基质中表达。系统发育研究表明，它是进化上最新出现的腱生蛋白，最早出现在硬骨鱼中。它在骨骼中的表达及其进化出现的时间应指导未来对其在骨形成、干细胞龛以及癌症治疗和检测中的作用的研究。
