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野生蚕中的细胞色素P450单加氧酶基因， 。 （你提供的原文似乎不完整）

Cytochrome P450 monooxygenase genes in the wild silkworm, .

作者信息

Wan Linrong, Zhou Anlian, Xiao Wenfu, Zou Bangxing, Jiang Yaming, Xiao Jinshu, Deng Cao, Zhang Youhong

机构信息

Sericultural Research Institute, Sichuan Academy of Agricultural Sciences, Nanchong, Sichuan, China.

College of Agronomy, Sichuan Agricultural University, Chengdu, Sichuan, China.

出版信息

PeerJ. 2021 Feb 3;9:e10818. doi: 10.7717/peerj.10818. eCollection 2021.

DOI:10.7717/peerj.10818
PMID:33604192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7866900/
Abstract

Wild ( and domestic silkworms () are good models for investigating insect domestication, as 5000 years of artificial breeding and selection have resulted in significant differences between and . In this study, we improved the genome assemblies to the chromosome level and updated the protein-coding gene annotations for . Based on this updated genome, we identified 68 cytochrome P450 genes in . The cytochrome P450 repository in is smaller than in . Certain currently unknown key genes, rather than gene number, are critical for insecticide resistance in which shows greater resistance to insecticides than . Based on the physical maps of we located 66 cytochrome P450s on 18 different chromosomes, and 27 of the cytochrome P450 genes were concentrated into seven clusters. KEGG enrichment analysis of the P450 genes revealed the involvement of cytochrome P450 genes in hormone biosynthesis. Analyses of the silk gland transcriptome identified candidate cytochrome P450 genes () involved in ecdysteroidogenesis and insecticide metabolism in .

摘要

野生（和家养）蚕是研究昆虫驯化的良好模型，因为5000年的人工育种和选择导致了野生蚕和家养蚕之间存在显著差异。在本研究中，我们将基因组组装提升到了染色体水平，并更新了家蚕的蛋白质编码基因注释。基于这个更新后的基因组，我们在家蚕中鉴定出了68个细胞色素P450基因。家蚕中的细胞色素P450基因库比野生蚕中的小。某些目前未知的关键基因而非基因数量，对家蚕的抗药性至关重要，家蚕比野生蚕对杀虫剂表现出更强的抗性。基于家蚕的物理图谱，我们将66个细胞色素P450基因定位在18条不同的染色体上，其中27个细胞色素P450基因集中在7个簇中。对P450基因的KEGG富集分析揭示了细胞色素P450基因参与激素生物合成。对丝腺转录组的分析确定了参与家蚕蜕皮激素生成和杀虫剂代谢的候选细胞色素P450基因（）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6043/7866900/d1e1b806d780/peerj-09-10818-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6043/7866900/4c21f4f964cc/peerj-09-10818-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6043/7866900/0c8469fc8ec4/peerj-09-10818-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6043/7866900/b201353da509/peerj-09-10818-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6043/7866900/101ee77c6985/peerj-09-10818-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6043/7866900/d1e1b806d780/peerj-09-10818-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6043/7866900/4c21f4f964cc/peerj-09-10818-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6043/7866900/0c8469fc8ec4/peerj-09-10818-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6043/7866900/b201353da509/peerj-09-10818-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6043/7866900/101ee77c6985/peerj-09-10818-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6043/7866900/d1e1b806d780/peerj-09-10818-g005.jpg

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