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从死亡数据推断新冠病毒真实感染率

Inferring True COVID19 Infection Rates From Deaths.

作者信息

McCulloh Ian, Kiernan Kevin, Kent Trevor

机构信息

Discovery Lab, Applied Intelligence, Accenture, Washington, DC, United States.

Whiting School of Engineering, Johns Hopkins University, Laurel, MD, United States.

出版信息

Front Big Data. 2020 Oct 15;3:565589. doi: 10.3389/fdata.2020.565589. eCollection 2020.

Abstract

The novel coronavirus, SARS-CoV-2, commonly known as COVID19 has become a global pandemic in early 2020. The world has mounted a global social distancing intervention on a scale thought unimaginable prior to this outbreak; however, the economic impact and sustainability limits of this policy create significant challenges for government leaders around the world. Understanding the future spread and growth of COVID19 is further complicated by data quality issues due to high numbers of asymptomatic patients who may transmit the disease yet show no symptoms; lack of testing resources; failure of recovered patients to be counted; delays in reporting hospitalizations and deaths; and the co-morbidity of other life-threatening illnesses. We propose a Monte Carlo method for inferring true case counts from observed deaths using clinical estimates of Infection Fatality Ratios and Time to Death. Findings indicate that current COVID19 confirmed positive counts represent a small fraction of actual cases, and that even relatively effective surveillance regimes fail to identify all infectious individuals. We further demonstrate that the miscount also distorts officials' ability to discern the peak of an epidemic, confounding efforts to assess the efficacy of various interventions.

摘要

新型冠状病毒SARS-CoV-2,通常称为COVID-19,在2020年初已成为全球大流行疾病。全世界已开展了规模在此次疫情爆发前被认为难以想象的全球社交距离干预措施;然而,这一政策对经济的影响以及可持续性限制给世界各国政府领导人带来了重大挑战。由于大量无症状患者可能传播疾病却无任何症状,数据质量问题使得了解COVID-19未来的传播和增长情况变得更加复杂;检测资源匮乏;康复患者未被统计在内;住院和死亡报告存在延迟;以及其他危及生命疾病的合并症。我们提出一种蒙特卡洛方法,利用感染致死率和死亡时间的临床估计值,从观察到的死亡人数推断实际病例数。研究结果表明,当前COVID-19确诊阳性病例数仅占实际病例的一小部分,而且即使是相对有效的监测制度也无法识别所有感染者。我们进一步证明,计数错误还会扭曲官员辨别疫情高峰的能力,从而混淆评估各种干预措施效果的努力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9492/7931884/530e15c87450/fdata-03-565589-g0001.jpg

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