1Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Biomedical Sciences Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM), Biomedical Sciences Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
Xenotransplantation. 2021 Jul;28(4):e12683. doi: 10.1111/xen.12683. Epub 2021 Mar 12.
Decellularized xenografts are an inherent component of regenerative medicine. Their preserved structure, mechanical integrity and biofunctional composition have well established them in reparative medicine for a diverse range of clinical indications. Nonetheless, their performance is highly influenced by their source (ie species, age, tissue) and processing (ie decellularization, crosslinking, sterilization and preservation), which govern their final characteristics and determine their success or failure for a specific clinical target. In this review, we provide an overview of the different sources and processing methods used in decellularized xenografts fabrication and discuss their effect on the clinical performance of commercially available decellularized xenografts.
去细胞异种移植物是再生医学的固有组成部分。它们保留的结构、机械完整性和生物功能成分使它们在修复医学中得到了广泛的应用，适用于多种临床适应证。然而，它们的性能受到其来源（即物种、年龄、组织）和处理方法（即去细胞化、交联、灭菌和保存）的强烈影响，这些因素决定了最终的特性，并决定了它们在特定临床目标中的成败。在这篇综述中，我们概述了用于制备去细胞异种移植物的不同来源和处理方法，并讨论了它们对市售去细胞异种移植物临床性能的影响。
