Printza Athanasia, Katotomichelakis Mihalis, Valsamidis Konstantinos, Metallidis Symeon, Panagopoulos Periklis, Panopoulou Maria, Petrakis Vasilis, Constantinidis Jannis
First Otolaryngology Department, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Otolaryngology Department, School of Health Sciences, Democritus University of Thrace, Dragana, 387479 Alexandroupoli, Greece.
J Clin Med. 2021 Mar 2;10(5):966. doi: 10.3390/jcm10050966.
A significant proportion of people infected with SARS-CoV-2 report a new onset of smell or taste loss. The duration of the chemosensory impairment and predictive factors of recovery are still unclear. We aimed to investigate the prevalence, temporal course and recovery predictors in patients who suffered from varying disease severity. Consecutive adult patients diagnosed to be infected with SARS-CoV-2 via reverse-transcription-polymerase chain reaction (RT-PCR) at two coronavirus disease-2019 (COVID-19) Reference Hospitals were contacted to complete a survey reporting chemosensory loss, severity, timing and duration, nasal symptoms, smoking, allergic rhinitis, chronic rhinosinusitis, comorbidities and COVID-19 severity. In a cross-sectional study, we contacted 182 patients and 150 responded. Excluding the critically ill patients, 38% reported gustatory and 41% olfactory impairment (74% severe/anosmia). Most of the patients (88%) recovered their sense of smell by two months (median: 11.5 days; IQR: 13.3). For 23%, the olfactory loss lasted longer than a month. There were no significant differences in the prevalence and duration of chemosensory loss between groups of varying COVID-19 severity, and sexes (all > 0.05). Moderate hyposmia resolved quicker than more severe loss ( = 0.04). Smell and taste loss are highly prevalent in COVID-19. Most patients recover fast, but nearly one out of ten have not recovered in two months.
相当一部分感染新型冠状病毒（SARS-CoV-2）的人报告出现了新的嗅觉或味觉丧失。化学感觉障碍的持续时间以及恢复的预测因素仍不清楚。我们旨在调查不同疾病严重程度患者的患病率、时间进程和恢复预测因素。我们联系了两家2019冠状病毒病（COVID-19）参考医院中通过逆转录聚合酶链反应（RT-PCR）确诊感染SARS-CoV-2的成年连续患者，以完成一项关于化学感觉丧失、严重程度、时间和持续时间、鼻部症状、吸烟、过敏性鼻炎、慢性鼻-鼻窦炎、合并症以及COVID-19严重程度的调查。在一项横断面研究中，我们联系了182名患者，150名患者做出了回应。排除危重症患者后，38%的患者报告有味觉障碍，41%的患者有嗅觉障碍（74%为重度/嗅觉丧失）。大多数患者（88%）在两个月内恢复了嗅觉（中位数：11.5天；四分位间距：13.3）。23%的患者嗅觉丧失持续时间超过一个月。不同COVID-19严重程度组和不同性别之间，化学感觉丧失的患病率和持续时间均无显著差异（均>0.05）。中度嗅觉减退比重度丧失恢复得更快（P = 0.04）。嗅觉和味觉丧失在COVID-19中非常普遍。大多数患者恢复迅速，但近十分之一的患者在两个月内尚未恢复。
