Longitudinal Study Section, Translation Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.
Nutrients. 2021 Mar 30;13(4):1129. doi: 10.3390/nu13041129.
Identifying modifying protective factors to promote healthy aging is of utmost public health importance. The frailty index (FI) reflects the accumulation of health deficits and is one widely used method to assess health trajectories in aging. Adherence to a Mediterranean-type diet (MTD) has been associated with favorable health trajectories. Therefore, this study explored whether adherence to a MTD is negatively associated with FI in the InCHIANTI study. Participants ( = 485) included individuals over 65 years of age at baseline with complete data over a follow-up period of 10 years. MTD was computed on a scale of 0-9 and categorized based on these scores into three groups of low (≤3), medium (4-5), and high (≥6) adherence. Being in a high or medium adherence group was associated with 0.03 and 0.013 unit lower FI scores over the follow-up period, compared to the low adherence group. In participants with a low FI at baseline, being in a high or medium MTD-adherence group had 0.004 and 0.005 unit/year slower progression of FI compared to the low adherence group. These study results support adherence to a MTD as a protective strategy to maintain a lower FI.
确定可促进健康老龄化的调节保护因素至关重要。衰弱指数（FI）反映了健康缺陷的积累，是评估衰老过程中健康轨迹的常用方法之一。遵循地中海式饮食（MTD）与有利的健康轨迹相关。因此，本研究探讨了在 INCHIANTI 研究中，MTD 依从性是否与 FI 呈负相关。参与者（n=485）包括基线时年龄超过 65 岁且在 10 年随访期间数据完整的个体。MTD 按 0-9 分的量表计算，并根据这些分数分为低（≤3）、中（4-5）和高（≥6）依从三组。与低依从组相比，在高或中依从组中 FI 评分在随访期间分别降低了 0.03 和 0.013 个单位。在基线 FI 较低的参与者中，与低依从组相比，高或中 MTD 依从组 FI 的进展速度每年分别减慢 0.004 和 0.005 个单位。这些研究结果支持 MTD 的依从性是维持较低 FI 的保护策略。
