Department of Paediatrics, The First People's Hospital of Xiaoshan District, Hangzhou, China.
Xiangya School of Medicine, Central South University, Changsha, China.
Pol J Microbiol. 2021 Mar;70(1):45-55. doi: 10.33073/pjm-2021-002. Epub 2021 Mar 9.
Several studies have shown that an increased risk of metabolic and immune disorders associated with cesarean section mode of delivery may exist. However, such studies have not been conducted in the Chinese population. Stool sample sequencing of the gene encoding the 16S rRNA of 82 prospectively enrolled 3- and 30-42-day-old vaginal and cesarean section delivered newborns was performed to study the composition and predicted function of the intestinal microbiota. In the samples from the 3-day-old neonates, the levels of in the two groups were similar. The genera , and were more prominent in the vaginal delivery than in the cesarean section group, which showed a predominance of , and . The differences between the two groups were statistically significant ( < 0.05). In the samples from 30- to 42-day-old infants, , and were the main genera present in the vaginal delivery group, while in the cesarean section delivery group; the predominant genera were , and . Predicted functions of the vaginal delivery group revealed higher metabolic and biodegradation rates of carbohydrates, vitamins, and xenobiotics than those in the cesarean section group, which contributed to the stability of the microbiota in the former. The abundance of probiotic bacteria such as and , and the negative correlation between obesity and presence were higher in vaginally delivered infants than in cesarean-delivered infants at both studied time points.
已有多项研究表明，剖宫产分娩方式可能会增加与代谢和免疫紊乱相关的风险。然而，此类研究尚未在中国人中开展。本研究前瞻性纳入 82 例 3 至 42 日龄的阴道分娩和剖宫产分娩的新生儿，对其粪便样本进行 16S rRNA 基因测序，以研究肠道微生物群的组成和预测功能。在 3 日龄新生儿的样本中，两组新生儿的 丰度相似。阴道分娩组中 、 和 的丰度高于剖宫产组，而剖宫产组中 、 和 的丰度较高。两组间差异具有统计学意义（<0.05）。在 30 至 42 日龄婴儿的样本中，阴道分娩组以 、 和 为主，而剖宫产组以 、 和 为主。阴道分娩组的预测功能显示，其碳水化合物、维生素和外源性物质的代谢和生物降解率高于剖宫产组，这有助于前者肠道微生物群的稳定。在两个研究时间点，阴道分娩婴儿中 、 和 等益生菌的丰度较高，肥胖与 丰度呈负相关。
