多维打印在骨组织工程中的应用。
Multi-Dimensional Printing for Bone Tissue Engineering.
机构信息
Department of Bioengineering, Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, CA, 90095, USA.
Stomatology Hospital, School of Stomatology, School of Medicine, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Clinical Research Center of Oral Disease of Zhejiang Province, Zhejiang University, Hangzhou, Zhejiang, 310006, China.
出版信息
Adv Healthc Mater. 2021 Jun;10(11):e2001986. doi: 10.1002/adhm.202001986. Epub 2021 Apr 19.
The development of 3D printing has significantly advanced the field of bone tissue engineering by enabling the fabrication of scaffolds that faithfully recapitulate desired mechanical properties and architectures. In addition, computer-based manufacturing relying on patient-derived medical images permits the fabrication of customized modules in a patient-specific manner. In addition to conventional 3D fabrication, progress in materials engineering has led to the development of 4D printing, allowing time-sensitive interventions such as programed therapeutics delivery and modulable mechanical features. Therapeutic interventions established via multi-dimensional engineering are expected to enhance the development of personalized treatment in various fields, including bone tissue regeneration. Here, recent studies utilizing 3D printed systems for bone tissue regeneration are summarized and advances in 4D printed systems are highlighted. Challenges and perspectives for the future development of multi-dimensional printed systems toward personalized bone regeneration are also discussed.
3D 打印技术的发展通过制造能够真实再现所需机械性能和结构的支架，极大地推动了骨组织工程领域的发展。此外，基于计算机的制造依赖于基于患者的医学图像，允许以患者特异性的方式制造定制模块。除了传统的 3D 制造，材料工程的进展还导致了 4D 打印的发展，允许进行时间敏感的干预，如程序治疗药物的输送和可调节的机械特性。通过多维工程建立的治疗干预措施有望增强个性化治疗在包括骨组织再生在内的各个领域的发展。在这里，总结了最近利用 3D 打印系统进行骨组织再生的研究进展，并强调了 4D 打印系统的进展。还讨论了多维打印系统向个性化骨再生发展的未来挑战和前景。
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