Department of Paediatric Nephrology, Wroclaw Medical University, 50-556 Wrocław, Poland.
Department of Clinical Pharmacology, Wroclaw Medical University, 50-556 Wrocław, Poland.
Int J Mol Sci. 2021 Apr 16;22(8):4132. doi: 10.3390/ijms22084132.
Currently in Europe, despite the many advances in production technology of synthetic drugs, the interest in natural herbal medicines continues to increase. One of the reasons for their popular use is the assumption that natural equals safe. However, herbal medicines contain pharmacologically active ingredients, some of which have been associated with adverse effects. Kidneys are particularly susceptible to injury induced by toxins, including poisonous constituents from medicinal plants. The most recognized herb-induced kidney injury is aristolochic acid nephropathy connected with misuse of certain Traditional Chinese herbal medicines. Data concerning nephrotoxicity of plant species of European origin are scarce. Here, we critically review significant data of the nephrotoxicity of several plants used in European phytotherapy, including , , and ). Causative mechanisms and factors predisposing to intoxications from the use of herbs are discussed. The basic intention of this review is to improve pharmacovigilance of herbal medicine, especially in patients with chronic kidney diseases.
目前在欧洲，尽管合成毒品的生产技术有了许多进步，但对天然草药的兴趣仍在持续增加。它们如此受欢迎的原因之一是人们认为天然的等同于安全的。然而，草药中含有具有药理活性的成分，其中一些已被认为会产生不良反应。肾脏尤其容易受到毒素的伤害，包括来自药用植物的有毒成分。最被认可的由草药引起的肾损伤是与滥用某些中药相关的马兜铃酸肾病。关于欧洲原产植物种的肾毒性的数据非常有限。在这里，我们批判性地回顾了几种用于欧洲植物疗法的植物的肾毒性的重要数据，包括（，（，（和（）。讨论了导致中毒的发病机制和易患因素。本综述的基本目的是提高草药的药物警戒性，特别是在慢性肾脏病患者中。
