通过配体设计构建无机纳米粒子与生物系统之间的界面

Huang Rui, Luther David C, Zhang Xianzhi, Gupta Aarohi, Tufts Samantha A, Rotello Vincent M

Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA.

Nanomaterials (Basel). 2021 Apr 13;11(4):1001. doi: 10.3390/nano11041001.

Nanoparticles (NPs) provide multipurpose platforms for a wide range of biological applications. These applications are enabled through molecular design of surface coverages, modulating NP interactions with biosystems. In this review, we highlight approaches to functionalize nanoparticles with "small" organic ligands (Mw < 1000), providing insight into how organic synthesis can be used to engineer NPs for nanobiology and nanomedicine.

纳米颗粒（NPs）为广泛的生物应用提供了多功能平台。这些应用是通过表面覆盖物的分子设计来实现的，从而调节纳米颗粒与生物系统的相互作用。在这篇综述中，我们重点介绍了用“小”有机配体（分子量<1000）对纳米颗粒进行功能化的方法，深入探讨了有机合成如何用于设计用于纳米生物学和纳米医学的纳米颗粒。