Zhang Tingwei, Kho Aaron M, Srinivasan Vivek J
Department of Biomedical Engineering, University of California, Davis, Davis, CA, United States.
Department of Ophthalmology and Vision Science, School of Medicine, University of California, Davis, Sacramento, CA, United States.
Front Cell Neurosci. 2021 Apr 29;15:655096. doi: 10.3389/fncel.2021.655096. eCollection 2021.
From the bipolar cells to higher brain visual centers, signals in the vertebrate visual system are transmitted along parallel on and off pathways. These two pathways are spatially segregated along the depth axis of the retina. Yet, to our knowledge, there is no way to directly assess this anatomical stratification . Here, employing ultrahigh resolution visible light Optical Coherence Tomography (OCT) imaging in humans, we report a stereotyped reflectivity pattern of the inner plexiform layer (IPL) that parallels IPL stratification. We characterize the topography of this reflectivity pattern non-invasively in a cohort of normal, young adult human subjects. This proposed correlate of IPL stratification is accessible through non-invasive ocular imaging in living humans. Topographic variations should be carefully considered when designing studies in development or diseases of the visual system.
从双极细胞到更高层次的脑视觉中枢，脊椎动物视觉系统中的信号沿着平行的开和关通路进行传递。这两条通路在视网膜的深度轴上在空间上是分隔开的。然而，据我们所知，尚无直接评估这种解剖分层的方法。在此，我们利用超高分辨率可见光光学相干断层扫描（OCT）对人类进行成像，报告了一种与内网状层（IPL）分层平行的IPL反射率模式。我们在一组正常的年轻成年人类受试者中对这种反射率模式的地形进行了非侵入性表征。这种所提出的IPL分层的相关特征可通过对活体人类进行非侵入性眼部成像获得。在设计视觉系统发育或疾病的研究时，应仔细考虑地形变化。
