School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK
Department of Movement and Sports Sciences, Ghent University, Gent, Belgium.
Br J Sports Med. 2021 Nov;55(22):1277-1285. doi: 10.1136/bjsports-2020-102345. Epub 2021 May 18.
To examine the joint associations of daily time spent in different intensities of physical activity, sedentary behaviour and sleep with all-cause mortality.
Federated pooled analysis of six prospective cohorts with device-measured time spent in different intensities of physical activity, sedentary behaviour and sleep following a standardised compositional Cox regression analysis.
130 239 people from general population samples of adults (average age 54 years) from the UK, USA and Sweden.
All-cause mortality (follow-up 4.3-14.5 years).
Studies using wrist and hip accelerometer provided statistically different results (I=92.2%, Q-test p<0.001). There was no association between duration of sleep and all-cause mortality, HR=0.96 (95% CI 0.67 to 1.12). The proportion of time spent in moderate to vigorous physical activity was significantly associated with lower risk of all-cause mortality (HR=0.63 (95% CI 0.55 to 0.71) wrist; HR=0.93 (95% CI 0.87 to 0.98) hip). A significant association for the ratio of time spent in light physical activity and sedentary time was only found in hip accelerometer-based studies (HR=0.5, 95% CI 0.42 to 0.62). In studies based on hip accelerometer, the association between moderate to vigorous physical activity and mortality was modified by the balance of time spent in light physical activity and sedentary time.
This federated analysis shows a joint dose-response association between the daily balance of time spent in physical activity of different intensities and sedentary behaviour with all-cause mortality, while sleep duration does not appear to be significant. The strongest association is with time spent in moderate to vigorous physical activity, but it is modified by the balance of time spent in light physical activity relative to sedentary behaviour.
研究不同强度的体力活动、久坐行为和睡眠的每日时间分配与全因死亡率的联合关联。
对六个前瞻性队列进行联合荟萃分析，使用设备测量不同强度的体力活动、久坐行为和睡眠的时间，并进行标准化的组成性 Cox 回归分析。
来自英国、美国和瑞典的一般人群样本中的 130239 名成年人（平均年龄 54 岁）。
全因死亡率（随访时间 4.3-14.5 年）。
使用腕部和髋部加速度计的研究提供了统计学上不同的结果（I=92.2%，Q 检验 p<0.001）。睡眠时间与全因死亡率之间没有关联，HR=0.96（95%CI 0.67-1.12）。中等至剧烈体力活动的时间比例与全因死亡率降低显著相关（腕部 HR=0.63（95%CI 0.55-0.71）；髋部 HR=0.93（95%CI 0.87-0.98））。仅在基于髋部加速度计的研究中发现轻体力活动和久坐时间的时间分配比例与死亡率之间存在显著关联（HR=0.5，95%CI 0.42-0.62）。在基于髋部加速度计的研究中，中等至剧烈体力活动与死亡率之间的关联受到轻体力活动和久坐时间的时间分配平衡的影响。
这项联合分析表明，不同强度的体力活动和久坐行为的日常平衡与全因死亡率之间存在联合剂量反应关联，而睡眠时间似乎没有显著影响。与中等至剧烈体力活动时间的关联最强，但受轻体力活动相对于久坐行为的时间分配平衡的影响。
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