Veziant Julie, Villéger Romain, Barnich Nicolas, Bonnet Mathilde
Microbes Intestin Inflammation et Susceptibilité de l'Hôte (M2iSH) UMR 1071 Inserm/Université Clermont Auvergne, USC-INRAE 2018, CRNH Auvergne, 63000 Clermont-Ferrand, France.
Department of Digestive, Hepatobiliary and Endocrine Surgery Paris Descartes University Cochin Hospital, 75000 Paris, France.
Cancers (Basel). 2021 May 5;13(9):2215. doi: 10.3390/cancers13092215.
The gut microbiota is crucial for physiological development and immunological homeostasis. Alterations of this microbial community called dysbiosis, have been associated with cancers such colorectal cancers (CRC). The pro-carcinogenic potential of this dysbiotic microbiota has been demonstrated in the colon. Recently the role of the microbiota in the efficacy of anti-tumor therapeutic strategies has been described in digestive cancers and in other cancers (e.g., melanoma and sarcoma). Different bacterial species seem to be implicated in these mechanisms: , and colibactin-associated (CoPEC). CoPEC bacteria are prevalent in the colonic mucosa of patients with CRC and they promote colorectal carcinogenesis in susceptible mouse models of CRC. In this review, we report preclinical and clinical data that suggest that CoPEC could be a new factor predictive of poor outcomes that could be used to improve cancer management. Moreover, we describe the possibility of using these bacteria as new therapeutic targets.
肠道微生物群对生理发育和免疫稳态至关重要。这种微生物群落的改变称为生态失调，与结直肠癌（CRC）等癌症有关。这种失调的微生物群的促癌潜力已在结肠中得到证实。最近，微生物群在抗肿瘤治疗策略疗效中的作用已在消化道癌症和其他癌症（如黑色素瘤和肉瘤）中得到描述。不同的细菌种类似乎与这些机制有关： 、 以及与大肠杆菌素相关的（致病性大肠杆菌）。致病性大肠杆菌在CRC患者的结肠黏膜中普遍存在，它们在CRC易感小鼠模型中促进结直肠癌的发生。在这篇综述中，我们报告了临床前和临床数据，这些数据表明致病性大肠杆菌可能是一个预测不良预后的新因素，可用于改善癌症管理。此外，我们描述了将这些细菌用作新治疗靶点的可能性。
