Docu Axelerad Any, Stroe Alina Zorina, Arghir Oana Cristina, Docu Axelerad Daniel, Gogu Anca Elena
Department of Neurology, General Medicine Faculty, Ovidius University, 900470 Constanta, Romania.
Department of Pneumology, Faculty of Medicine, Ovidius University of Constanta, 900470 Constanta, Romania.
Brain Sci. 2021 May 4;11(5):595. doi: 10.3390/brainsci11050595.
Respiratory dysfunctions have been associated with Parkinson's disease since the first observations of the disease in 1817. Patients with Parkinson's disease frequently present respiratory disorders with obstructive ventilatory patterns and restrictive modifications, as well as limitations in respiratory volumes. In addition, respiratory impairments are observed due to the rigidity and kyphosis that Parkinson's disease patients experience. Subsidiary pulmonary complications can also appear as side effects of medication. Silent aspiration can be the cause of pneumonia in Parkinson's disease. Pulmonary dysfunction is one of the main factors that leads to the morbidity and mortality of patients with Parkinson's disease. Here, we performed a narrative review of the literature and reviewed studies on dyspnea, lung volumes, respiratory muscle function, sleep breathing disorders, and subsidiary speech and swallow impairments related to pulmonary dysfunction in patients with Parkinson's disease.
自1817年首次发现帕金森病以来，呼吸功能障碍就一直与该疾病相关。帕金森病患者经常出现呼吸障碍，表现为阻塞性通气模式和限制性改变，以及呼吸容量受限。此外，帕金森病患者因出现僵硬和脊柱后凸而导致呼吸功能受损。肺部并发症也可能作为药物的副作用出现。隐性误吸可能是帕金森病患者发生肺炎的原因。肺功能障碍是导致帕金森病患者发病和死亡的主要因素之一。在此，我们对文献进行了叙述性综述，并回顾了有关帕金森病患者肺功能障碍相关的呼吸困难、肺容量、呼吸肌功能、睡眠呼吸障碍以及辅助性言语和吞咽障碍的研究。
