纽约市哮喘儿童和非哮喘儿童家庭中的维多利亚毕赤酵母（同义Cryptococcus victoriae）。
Vishniacozyma victoriae (syn. Cryptococcus victoriae) in the homes of asthmatic and non-asthmatic children in New York City.
机构信息
Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA.
Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.
出版信息
J Expo Sci Environ Epidemiol. 2022 Jan;32(1):48-59. doi: 10.1038/s41370-021-00342-4. Epub 2021 Jun 5.
BACKGROUND
Indoor environments contain a broad diversity of non-pathogenic Basidiomycota yeasts, but their role in exacerbating adverse health effects has remained unclear.
OBJECTIVE
To understand the role of Vishniacozyma victoriae exposure and its impact on human health.
METHODS
A qPCR assay was developed to detect and quantify an abundant indoor yeast species, Vishniacozyma victoriae (syn. Cryptococcus victoriae), from homes participating in the New York City Neighborhood Asthma and Allergy Study (NAAS). We evaluated the associations between V. victoriae, housing characteristics, and asthma relevant health endpoints.
RESULTS
V. victoriae was quantified in 236 of the 256 bedroom floor dust samples ranging from less than 300-45,918 cell equivalents/mg of dust. Higher concentrations of V. victoriae were significantly associated with carpeted bedroom floors (P = 0.044), mean specific humidity (P = 0.004), winter (P < 0.0001) and spring (P = 0.001) seasons, and the presence of dog (P = 0.010) and dog allergen Can f 1 (P = 0.027). V. victoriae concentrations were lower in homes of children with asthma vs. without asthma (P = 0.027), an association observed only among the non-seroatopic children.
背景
室内环境中含有广泛多样的非致病性担子菌酵母菌，但它们在加剧不良健康影响方面的作用仍不清楚。
目的
了解 Vishniacozyma victoriae 暴露的作用及其对人类健康的影响。
方法
开发了一种 qPCR 检测方法，用于检测和定量室内丰度较高的酵母物种 Vishniacozyma victoriae（同义词：Cryptococcus victoriae），该检测方法来自参与纽约市社区哮喘和过敏研究（NAAS）的家庭。我们评估了 V. victoriae、住房特征与哮喘相关健康终点之间的关联。
结果
在 256 个卧室地板灰尘样本中的 236 个样本中定量了 V. victoriae，范围从不到 300-45918 个细胞当量/mg 灰尘。V. victoriae 的浓度较高与卧室铺有地毯（P=0.044）、平均比湿度（P=0.004）、冬季（P<0.0001）和春季（P=0.001）以及存在狗（P=0.010）和狗过敏原 Can f 1（P=0.027）显著相关。患有哮喘的儿童家中的 V. victoriae 浓度低于无哮喘的儿童（P=0.027），这种关联仅在非血清阳性的儿童中观察到。
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