经典但颇具争议的脂质合成第一酶：大肠杆菌乙酰辅酶 A 羧化酶。
The Classical, Yet Controversial, First Enzyme of Lipid Synthesis: Escherichia coli Acetyl-CoA Carboxylase.
机构信息
Department of Microbiology, University of Illinois, Urbana, Illinois, USA.
Department of Biochemistry, University of Illinois, Urbana, Illinois, USA.
出版信息
Microbiol Mol Biol Rev. 2021 Aug 18;85(3):e0003221. doi: 10.1128/MMBR.00032-21. Epub 2021 Jun 16.
Abstract
Escherichia coli acetyl-CoA carboxylase (ACC), the enzyme responsible for synthesis of malonyl-CoA, the building block of fatty acid synthesis, is the paradigm bacterial ACC. Many reports on the structures and stoichiometry of the four subunits comprising the active enzyme as well as on regulation of ACC activity and expression have appeared in the almost 20 years since this subject was last reviewed. This review seeks to update and expand on these reports.
摘要
大肠杆菌乙酰辅酶 A 羧化酶（ACC）是合成丙二酰辅酶 A 的酶，丙二酰辅酶 A 是脂肪酸合成的结构单元，是典型的细菌 ACC。自上次对此主题进行综述以来的近 20 年中，已经有许多关于构成活性酶的四个亚基的结构和化学计量比以及 ACC 活性和表达调控的报告。本综述旨在更新和扩展这些报告。
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