David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nat Biomed Eng. 2021 Oct;5(10):1115-1130. doi: 10.1038/s41551-021-00739-4. Epub 2021 Jun 21.
Silicone is widely used in chronic implants and is generally perceived to be safe. However, textured breast implants have been associated with immune-related complications, including malignancies. Here, by examining for up to one year the foreign body response and capsular fibrosis triggered by miniaturized or full-scale clinically approved breast implants with different surface topography (average roughness, 0-90 μm) placed in the mammary fat pads of mice or rabbits, respectively, we show that surface topography mediates immune responses to the implants. We also show that the surface surrounding human breast implants collected during revision surgeries also differentially alters the individual's immune responses to the implant. Moreover, miniaturized implants with an average roughness of 4 μm can largely suppress the foreign body response and fibrosis (but not in T-cell-deficient mice), and that tissue surrounding these implants displayed higher levels of immunosuppressive FOXP3 regulatory T cells. Our findings suggest that, amongst the topographies investigated, implants with an average roughness of 4 μm provoke the least amount of inflammation and foreign body response.
硅树脂被广泛应用于慢性植入物，通常被认为是安全的。然而，纹理乳房植入物与免疫相关的并发症有关，包括恶性肿瘤。在这里，通过分别在小鼠或兔的乳腺脂肪垫中植入微型或全尺寸临床批准的、具有不同表面形貌（平均粗糙度 0-90μm）的乳房植入物，检查长达一年的异物反应和包膜纤维化，我们表明表面形貌介导了对植入物的免疫反应。我们还表明，在修复手术中收集的人类乳房植入物周围的表面也会改变个体对植入物的免疫反应。此外，平均粗糙度为 4μm 的微型植入物可以很大程度上抑制异物反应和纤维化（但在 T 细胞缺陷小鼠中则不然），并且这些植入物周围的组织显示出更高水平的免疫抑制性 FOXP3 调节性 T 细胞。我们的研究结果表明，在所研究的形貌中，平均粗糙度为 4μm 的植入物引起的炎症和异物反应最少。
