Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA.
Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
Nat Commun. 2021 Jun 22;12(1):3844. doi: 10.1038/s41467-021-24101-z.
The ability to precisely manipulate nano-objects on a large scale can enable the fabrication of materials and devices with tunable optical, electromagnetic, and mechanical properties. However, the dynamic, parallel manipulation of nanoscale colloids and materials remains a significant challenge. Here, we demonstrate acoustoelectronic nanotweezers, which combine the precision and robustness afforded by electronic tweezers with versatility and large-field dynamic control granted by acoustic tweezing techniques, to enable the massively parallel manipulation of sub-100 nm objects with excellent versatility and controllability. Using this approach, we demonstrated the complex patterning of various nanoparticles (e.g., DNAs, exosomes, ~3 nm graphene flakes, ~6 nm quantum dots, ~3.5 nm proteins, and ~1.4 nm dextran), fabricated macroscopic materials with nano-textures, and performed high-resolution, single nanoparticle manipulation. Various nanomanipulation functions, including transportation, concentration, orientation, pattern-overlaying, and sorting, have also been achieved using a simple device configuration. Altogether, acoustoelectronic nanotweezers overcome existing limitations in nano-manipulation and hold great potential for a variety of applications in the fields of electronics, optics, condensed matter physics, metamaterials, and biomedicine.
大规模精确操纵纳米物体的能力可以实现具有可调光学、电磁和机械性能的材料和器件的制造。然而,纳米胶体和材料的动态、并行操纵仍然是一个重大挑战。在这里,我们展示了声电子纳米镊子,它将电子镊子的精确性和鲁棒性与声镊子技术提供的多功能性和大场动态控制相结合,能够实现具有出色多功能性和可控性的亚 100nm 物体的大规模并行操纵。使用这种方法,我们展示了各种纳米粒子(例如 DNA、外泌体、3nm 石墨烯片、6nm 量子点、3.5nm 蛋白质和1.4nm 葡聚糖)的复杂图案化,制造了具有纳米纹理的宏观材料,并进行了高分辨率、单颗粒操纵。通过简单的设备配置,还实现了各种纳米操作功能,包括运输、浓缩、定向、图案叠加和分类。总之,声电子纳米镊子克服了现有纳米操作的局限性,在电子学、光学、凝聚态物理、超材料和生物医学等领域的各种应用中具有巨大的潜力。