Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
Phytochemistry. 2021 Oct;190:112846. doi: 10.1016/j.phytochem.2021.112846. Epub 2021 Jul 3.
Euphorbiaceae is one of the largest families of higher plants, including 7500 species, and many of them are used as medicines in China. From 2013 to 2019, a total of 455 previously undescribed diterpenoids were isolated from 53 species of Euphorbia, and some skeleton types were first discovered from the genus Euphorbia. Most of the diterpenoids isolated from Euphorbia spp. have been tested for their biological activity, and some of them were first reported for Euphorbia diterpenoids in recent years, such as neuroprotection, antimalarial activity and inhibition of osteoclast formation. In this review, we summarize all the isolated diterpenoids from the genus Euphorbia according to their skeleton types, classify all these diterpenoids into 26 normal classes and 37 novel skeleton types, and summarize their biological activity.
大戟科是高等植物中最大的科之一，包括 7500 种，其中许多在中国被用作药物。从 2013 年到 2019 年，从 53 种大戟属植物中总共分离出了 455 种以前未描述的二萜类化合物，其中一些骨架类型是首次从大戟属中发现的。从大戟属植物中分离得到的大多数二萜类化合物都进行了生物活性测试，其中一些是近年来首次报道的大戟二萜类化合物，如神经保护、抗疟活性和抑制破骨细胞形成。在这篇综述中，我们根据骨架类型总结了大戟属植物中所有分离得到的二萜类化合物，将所有这些二萜类化合物分为 26 个普通类和 37 个新型骨架类型，并总结了它们的生物活性。
