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堪萨斯分枝杆菌酚糖脂（霉菌酸A）免疫血清的特异性

Specificity of a Mycobacterium kansasii phenolic glycolipid (mycoside A) immunoserum.

作者信息

Papa F, Riviere M, Fournié J J, Puzo G, David H

机构信息

Service de la Tuberculose et des Mycobactéries, Institut Pasteur, Paris, France.

出版信息

J Clin Microbiol. 1987 Dec;25(12):2270-3. doi: 10.1128/jcm.25.12.2270-2273.1987.

DOI:10.1128/jcm.25.12.2270-2273.1987
PMID:3429620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC269468/
Abstract

The specificity of Mycobacterium kansasii anti-mycoside A antiserum prepared in rabbits injected with purified samples of the phenolic glycolipid was evaluated by an enzyme-linked immunosorbent assay. Chloroform-methanol extracts from representative strains of 23 mycobacterial species and 50 strains of M. kansasii showed that all strains of M. kansasii and the representative strain of M. gastri formed the antigen, whereas none of the remaining species (including M. leprae) formed it. Consequently, it was found that the antiserum was highly specific and useful for diagnostic purposes.

摘要

通过酶联免疫吸附测定法评估了用酚糖脂纯化样品注射兔制备的堪萨斯分枝杆菌抗霉菌素A抗血清的特异性。来自23种分枝杆菌代表性菌株和50株堪萨斯分枝杆菌的氯仿-甲醇提取物表明，所有堪萨斯分枝杆菌菌株和胃分枝杆菌代表性菌株形成抗原，而其余物种（包括麻风分枝杆菌）均未形成抗原。因此，发现该抗血清具有高度特异性，可用于诊断目的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dee/269468/45c4a5843167/jcm00096-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dee/269468/b0f1ea8b6078/jcm00096-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dee/269468/45c4a5843167/jcm00096-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dee/269468/b0f1ea8b6078/jcm00096-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dee/269468/45c4a5843167/jcm00096-0038-b.jpg

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本文引用的文献

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Phenol-Soluble Antigens from Mycobacterium kansasii, Mycobacterium gastri, and Mycobacterium marinum.堪萨斯分枝杆菌、胃分枝杆菌和海分枝杆菌的酚可溶性抗原。
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Structure of the specific oligosaccharides from the glycopeptidolipid antigens of serovars in the Mycobacterium avium-Mycobacterium intracellulare-Mycobacterium scrofulaceum complex.鸟分枝杆菌-胞内分枝杆菌-瘰疬分枝杆菌复合群血清型糖肽脂抗原中特定寡糖的结构
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Enzyme immunoassay for identification of heat-killed mycobacteria belonging to the Mycobacterium tuberculosis and Mycobacterium avium complexes and derived from early cultures.用于鉴定源自早期培养物的属于结核分枝杆菌复合群和鸟分枝杆菌复合群的热灭活分枝杆菌的酶免疫测定法。
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一种来自麻风分枝杆菌的新型酚糖脂，可能与免疫原性和致病性有关。
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4
Serological activity of a characteristic phenolic glycolipid from Mycobacterium leprae in sera from patients with leprosy and tuberculosis.麻风分枝杆菌特征性酚糖脂在麻风病和结核病患者血清中的血清学活性。
Clin Exp Immunol. 1983 May;52(2):271-9.
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Chemical synthesis and serology of disaccharides and trisaccharides of phenolic glycolipid antigens from the leprosy bacillus and preparation of a disaccharide protein conjugate for serodiagnosis of leprosy.麻风杆菌酚糖脂抗原二糖和三糖的化学合成与血清学研究以及用于麻风病血清诊断的二糖蛋白偶联物的制备
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A serological test for leprosy with a glycolipid specific for Mycobacterium leprae.一种用于麻风病的血清学检测方法，该方法使用一种对麻风分枝杆菌具有特异性的糖脂。
Science. 1983 Sep 9;221(4615):1057-9. doi: 10.1126/science.6348948.
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Structure and antigenicity of the major specific glycolipid antigen of Mycobacterium leprae.麻风分枝杆菌主要特异性糖脂抗原的结构与抗原性
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Serologic identification and classification of the atypical mycobacteria by their agglutination.通过凝集反应对非典型分枝杆菌进行血清学鉴定和分类。
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[Deoxysugars isolated from mycoside A: identification of acetyl derivatives of methyl 2,4-DI-O-methyl-rhamnopyranoside, 2-O-methyl-rhamofuranoside, 3-O-methyl-rhamnofuranoside, 2-O-methyl-fucopyranoside and 3-O-methyl-fucofuranoside].从霉菌糖苷A中分离出的脱氧糖：2,4-二-O-甲基鼠李糖吡喃糖苷、2-O-甲基鼠李糖呋喃糖苷、3-O-甲基鼠李糖呋喃糖苷、2-O-甲基岩藻糖吡喃糖苷和3-O-甲基岩藻糖呋喃糖苷的乙酰衍生物的鉴定
Bull Soc Chim Biol (Paris). 1970 Jul 18;52(6):679-93.