de Lima Lucas Pinheiro, de Paula Barbosa Antony
Faculdade Ana Carolina Puga (FAPUGA), Av. Braz Olaia Acosta, 1.900/ 109, Ribeirão Preto, 14026-610, São Paulo, Brazil.
Heliyon. 2021 Jul 31;7(8):e07695. doi: 10.1016/j.heliyon.2021.e07695. eCollection 2021 Aug.
Dietary supplementation containing extract is being widely used for weight loss due to its anti-adipogenic and antioxidant effects that regulate the metabolism of fatty acids. Bioactive compounds upregulate PPARα in the liver tissue, increasing oxidation of fatty acids and improving insulin sensitivity in addition to decreasing the expression of genes involved in the synthesis of fatty acids, such as LXRα and FAS. Studies on synephrine demonstrated their ability to stimulate the development of beige adipose tissue through greater expression of UCP1 and mtTFA, contributing to an increase in thermogenesis and mitochondrial biogenesis. However, despite its widespread use to reduce abdominal fat, few scientific studies have consensually proven the effectiveness of Moro orange extract for weight loss. This literature review summarizes the current information on the pharmacological and molecular mechanisms involved in the modulation of lipid metabolism by the bioactive compounds present in Moro orange extract.
由于其具有调节脂肪酸代谢的抗脂肪生成和抗氧化作用，含有提取物的膳食补充剂正被广泛用于减肥。生物活性化合物上调肝脏组织中的PPARα，增加脂肪酸氧化并改善胰岛素敏感性，此外还降低参与脂肪酸合成的基因（如LXRα和FAS）的表达。对辛弗林的研究表明，它们能够通过更高水平的UCP1和mtTFA表达来刺激米色脂肪组织的发育，有助于增加产热和线粒体生物发生。然而，尽管它被广泛用于减少腹部脂肪，但很少有科学研究一致证明摩洛橙提取物对减肥的有效性。这篇文献综述总结了目前关于摩洛橙提取物中生物活性化合物调节脂质代谢所涉及的药理和分子机制的信息。
