Department of Research, Sir Ganga Ram Hospital, New Delhi, India.
Front Cell Infect Microbiol. 2021 Sep 14;11:744903. doi: 10.3389/fcimb.2021.744903. eCollection 2021.
The outbreak of COVID-19 has proven to be an unprecedented disaster for the whole world. The virus has inflicted billion of lives across the globe in all aspects-physically, psychologically, as well as socially. Compared to the previous strains of β-CoV genera- MERS and SARS, SARS-CoV-2 has significantly higher transmissibility and worst post-recovery implications. A frequent mutation in the initial SARS-CoV-2 strain has been a major cause of mortalities (approx. 3 million deaths) and uncontrolled virulence (approx. 1 billion positive cases). As far as clinical manifestations are concerned, this particular virus has exhibited deleterious impacts on systems other than the respiratory system (primary target organ), such as the brain, hematological system, liver, kidneys, endocrine system, etc. with no promising curatives to date. Lack of emergency treatments and shortage of life-saving drugs has promoted the repurposing of existing therapeutics along with the emergence of vaccines with the combined efforts of scientists and industrial experts in this short span. This review summarizes every detail on COVID-19 and emphasizes undermining the future approaches to minimize its prevalence to the remaining lives.
COVID-19 的爆发对全世界来说是一场前所未有的灾难。该病毒在身体、心理和社会等各个方面给全球数亿人带来了伤害。与之前的β-CoV 属的 MERS 和 SARS 株相比，SARS-CoV-2 的传染性显著更高，且康复后的影响也更严重。SARS-CoV-2 初始株的频繁突变是导致高死亡率（约 300 万人死亡）和不可控毒力（约 10 亿例阳性病例）的主要原因。就临床表现而言，这种特殊病毒对呼吸系统（主要靶器官）以外的系统也产生了有害影响，如大脑、血液系统、肝脏、肾脏、内分泌系统等，目前尚无有效的治疗方法。缺乏紧急治疗方法和救命药物，促使科学家和工业专家在短时间内共同努力，重新利用现有的治疗方法，并开发出疫苗。本综述总结了 COVID-19 的每一个细节，并强调了未来降低其流行率以保护剩余生命的方法。
