Wands J R, Fujita Y K, Isselbacher K J, Degott C, Schellekens H, Dazza M C, Thiers V, Tiollais P, Brechot C
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6608-12. doi: 10.1073/pnas.83.17.6608.
We have identified long-incubation viral agents that share epitopes with hepatitis B virus (HBV). During chimpanzee infectivity studies, these agents may be recognized in the liver since they possess complementary nucleic acid sequences with HBV DNA; the genomic size was found to be 3.2 kilobases, identical to that of HBV. Liver injury was produced and there was antigen expression in hepatocytes. Chimpanzees were not protected by prior immunization with hepatitis B surface antigen; conversely, they were still susceptible to HBV after recovery from infection with such agents. These findings suggest that these hepatitis B virus-related variants appear to be immunologically distinct from HBV.
我们已经鉴定出了与乙型肝炎病毒（HBV）具有共同表位的长潜伏期病毒因子。在黑猩猩感染性研究中，这些因子可能在肝脏中被识别，因为它们拥有与HBV DNA互补的核酸序列；其基因组大小为3.2千碱基，与HBV相同。会产生肝损伤，并且在肝细胞中有抗原表达。黑猩猩不会因先前接种乙型肝炎表面抗原而受到保护；相反，它们在感染此类因子康复后仍易感染HBV。这些发现表明，这些与乙型肝炎病毒相关的变体在免疫方面似乎与HBV不同。
