Duan Lijuan, Li Mengying, Wang Changming, Qiao Yuanhua, Wang Zeyu, Sha Sha, Li Mingai
Faculty of Information Technology, Beijing University of Technology, Beijing, China.
Beijing Key Laboratory of Trusted Computing, Beijing, China.
Front Hum Neurosci. 2021 Oct 8;15:727139. doi: 10.3389/fnhum.2021.727139. eCollection 2021.
Sleep staging is one of the important methods to diagnosis and treatment of sleep diseases. However, it is laborious and time-consuming, therefore, computer assisted sleep staging is necessary. Most of the existing sleep staging researches using hand-engineered features rely on prior knowledges of sleep analysis, and usually single channel electroencephalogram (EEG) is used for sleep staging task. Prior knowledge is not always available, and single channel EEG signal cannot fully represent the patient's sleeping physiological states. To tackle the above two problems, we propose an automatic sleep staging network model based on data adaptation and multimodal feature fusion using EEG and electrooculogram (EOG) signals. 3D-CNN is used to extract the time-frequency features of EEG at different time scales, and LSTM is used to learn the frequency evolution of EOG. The nonlinear relationship between the High-layer features of EEG and EOG is fitted by deep probabilistic network. Experiments on SLEEP-EDF and a private dataset show that the proposed model achieves state-of-the-art performance. Moreover, the prediction result is in accordance with that from the expert diagnosis.
睡眠分期是睡眠疾病诊断和治疗的重要方法之一。然而,它既费力又耗时,因此,计算机辅助睡眠分期是必要的。现有的大多数使用手工设计特征的睡眠分期研究依赖于睡眠分析的先验知识,并且通常使用单通道脑电图(EEG)进行睡眠分期任务。先验知识并非总是可用,并且单通道EEG信号不能完全代表患者的睡眠生理状态。为了解决上述两个问题,我们提出了一种基于数据自适应和使用脑电图(EEG)和眼电图(EOG)信号的多模态特征融合的自动睡眠分期网络模型。3D-CNN用于提取不同时间尺度下EEG的时频特征,LSTM用于学习EOG的频率演变。通过深度概率网络拟合EEG和EOG高层特征之间的非线性关系。在SLEEP-EDF和一个私人数据集上的实验表明,所提出的模型取得了领先的性能。此外,预测结果与专家诊断结果一致。