Biopulse Srl, Naples, Italy.
Equivet Roma Hospital, Rome, Italy.
Open Vet J. 2021 Jul-Sep;11(3):385-389. doi: 10.5455/OVJ.2021.v11.i3.8. Epub 2021 Jul 29.
Electrochemotherapy (ECT) promotes the increased uptake of antitumor agents through the administration of permeabilizing electric pulses, thus enhancing chemotherapy effectiveness.
Our study aimed to describe the tolerability and efficacy of ECT alone or in association with surgery to manage solid neoplasms in equids.
Medical records of equids with a diagnosis of malignant tumors treated with ECT alone or in combination with surgery were retrospectively evaluated. Each equid received local treatment within the tumors or the tumors' bed with cisplatin at the dose of 0.5 mg/cm. Trains of permeabilizing biphasic electric pulses were then applied under spinal or general anesthesia.
Sixteen equids were enrolled in this study. There were nine melanoma cases, four fibrosarcoma, and three squamous cell carcinoma. Of those 16 equids, 7 received ECT for treatment of intraoperative local disease, while in 9 cases, ECT was the only treatment modality. The seven equids treated with the combination of ECT and surgery still have no evidence of disease at different times ranging from 9 to 60 months. The remaining nine had the following responses: two complete remissions, five partial responses, one stable disease, and one progressive disease. The treatment was well-tolerated, and local side effects were minimal. No systemic effects were documented.
This retrospective study suggests that ECT may be beneficial for equids with solid neoplasms and could be a useful addition to the current therapeutic options considering its low cost, limited toxicity, and ease of administration.
电化疗（ECT）通过给予致孔电脉冲来促进抗肿瘤药物的摄取增加，从而提高化疗效果。
我们的研究旨在描述 ECT 单独或联合手术治疗马属动物实体瘤的耐受性和疗效。
回顾性评估了诊断为恶性肿瘤并接受 ECT 单独或联合手术治疗的马属动物的病历。每匹马在肿瘤内或肿瘤床内接受顺铂 0.5mg/cm 的局部治疗。然后在脊髓或全身麻醉下应用致孔双相电脉冲列车。
本研究纳入了 16 匹马。其中 9 例为黑色素瘤，4 例为纤维肉瘤，3 例为鳞状细胞癌。在这 16 匹马中，有 7 匹在手术中接受了 ECT 治疗局部疾病，而在 9 例中，ECT 是唯一的治疗方式。在接受 ECT 和手术联合治疗的 7 匹马中，不同时间（9 至 60 个月）仍无疾病证据。其余 9 例的反应如下：2 例完全缓解，5 例部分缓解，1 例稳定疾病，1 例进展性疾病。该治疗耐受性良好，局部副作用极小。未记录到全身效应。
这项回顾性研究表明，ECT 可能对马属动物的实体瘤有益，并且由于其成本低、毒性有限且易于管理，可能是当前治疗选择的有用补充。
