College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China.
National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China.
Nutrients. 2021 Oct 29;13(11):3891. doi: 10.3390/nu13113891.
Probiotic intake has been shown to improve certain physiological health indicators. We aimed to examine effects of LTL1879, obtained from long-lived elderly volunteers, on blood biochemical, oxidative, and inflammatory markers and gut microbiota in twenty healthy, young volunteers. Volunteers were randomly divided into equal probiotic and placebo groups and changes in blood biochemical indicators, oxidative and inflammatory markers, and gut microbiota were examined after three weeks of probiotic intervention. The probiotic group's antioxidant levels were significantly enhanced post-intervention. Total antioxidant capacity (T-AOC) levels were significantly increased ( < 0.0001), while malondialdehyde (MDA) levels decreased ( < 0.05), and total superoxide dismutase (T-SOD) levels increased, but with no significant difference. In addition, Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) levels were significantly up-regulated and down-regulated ( < 0.05, respectively). , , and expression was significantly reduced ( < 0.05), while , , and expression increased ( < 0.05). Volunteer health status was quantified using principal components and cluster analysis, indicating that the probiotic group's overall score was higher than that of the placebo group. The results of this pilot study suggest LTL 1879 can significantly improve specific immune, oxidative, and gut microbiota characteristics related to health factors.
益生菌摄入已被证明能改善某些生理健康指标。我们旨在研究从长寿老年人志愿者中获得的 LTL1879 对 20 名健康年轻志愿者的血液生化、氧化和炎症标志物以及肠道微生物群的影响。志愿者随机分为益生菌组和安慰剂组，在益生菌干预 3 周后，检查血液生化指标、氧化和炎症标志物以及肠道微生物群的变化。益生菌组的抗氧化水平在干预后显著增强。总抗氧化能力（T-AOC）水平显著升高（<0.0001），而丙二醛（MDA）水平降低（<0.05），总超氧化物歧化酶（T-SOD）水平升高，但无显著差异。此外，白细胞介素-10（IL-10）和肿瘤坏死因子-α（TNF-α）水平显著上调和下调（分别为<0.05）。 、 、 和 表达明显减少（<0.05），而 、 、 和 表达增加（<0.05）。使用主成分和聚类分析对志愿者的健康状况进行量化，表明益生菌组的总评分高于安慰剂组。这项初步研究的结果表明，LTL1879 可以显著改善与健康因素相关的特定免疫、氧化和肠道微生物群特征。
