Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Yongin, Gyeonggi-do, Republic of Korea.
BUD.on Inc, Jeonju, Republic of Korea.
PLoS One. 2021 Dec 1;16(12):e0260612. doi: 10.1371/journal.pone.0260612. eCollection 2021.
Most existing electrocardiogram (ECG) feature extraction methods rely on rule-based approaches. It is difficult to manually define all ECG features. We propose an unsupervised feature learning method using a convolutional variational autoencoder (CVAE) that can extract ECG features with unlabeled data. We used 596,000 ECG samples from 1,278 patients archived in biosignal databases from intensive care units to train the CVAE. Three external datasets were used for feature validation using two approaches. First, we explored the features without an additional training process. Clustering, latent space exploration, and anomaly detection were conducted. We confirmed that CVAE features reflected the various types of ECG rhythms. Second, we applied CVAE features to new tasks as input data and CVAE weights to weight initialization for different models for transfer learning for the classification of 12 types of arrhythmias. The f1-score for arrhythmia classification with extreme gradient boosting was 0.86 using CVAE features only. The f1-score of the model in which weights were initialized with the CVAE encoder was 5% better than that obtained with random initialization. Unsupervised feature learning with CVAE can extract the characteristics of various types of ECGs and can be an alternative to the feature extraction method for ECGs.
大多数现有的心电图(ECG)特征提取方法都依赖于基于规则的方法。手动定义所有 ECG 特征是很困难的。我们提出了一种使用卷积变分自动编码器(CVAE)的无监督特征学习方法,该方法可以使用未标记的数据提取 ECG 特征。我们使用了来自重症监护病房生物信号数据库中的 1278 名患者的 596000 个 ECG 样本来训练 CVAE。我们使用了三个外部数据集,通过两种方法进行特征验证。首先,我们在没有额外训练过程的情况下探索了特征。进行了聚类、潜在空间探索和异常检测。我们确认 CVAE 特征反映了各种类型的 ECG 节律。其次,我们将 CVAE 特征作为输入数据应用于新任务,并将 CVAE 权重应用于不同模型的权重初始化,以进行心律失常分类的迁移学习。仅使用 CVAE 特征进行极端梯度提升的心律失常分类的 f1 分数为 0.86。使用 CVAE 编码器初始化权重的模型的 f1 分数比随机初始化的分数高出 5%。使用 CVAE 进行无监督特征学习可以提取各种类型的 ECG 的特征,并且可以替代 ECG 的特征提取方法。