Boustouller Y L, Johnson A P
Genitourin Med. 1986 Dec;62(6):380-3. doi: 10.1136/sti.62.6.380.
To assess the sensitivity of Gardnerella vaginalis to the complement mediated bactericidal activity of serum, six laboratory strains were incubated with normal human serum and two strains freshly isolated from women with non-specific vaginitis (NSV) were each incubated with homologous patient serum. There was no significant difference between the number of organisms recovered from unheated or heat inactivated serum after incubation at 37 degrees C for one hour with any of the strains tested. A suspension of G vaginalis incubated at 37 degrees C for one hour in heat inactivated homologous mouse antiserum with unheated normal human serum as a source of complement did not show any less viability than the control mixture using heat inactivated human serum. In contrast, a serum resistant strain of Neisseria gonorrhoeae incubated in heat inactivated homologous mouse antiserum with unheated normal human serum showed noticeably less viability than the control. G vaginalis therefore seems to be resistant to the bactericidal activity of both normal and immune serum.
为评估阴道加德纳菌对血清补体介导的杀菌活性的敏感性，将6株实验室菌株与正常人血清一起孵育，将2株从患有非特异性阴道炎（NSV）的女性中新鲜分离出的菌株分别与同源患者血清一起孵育。在37℃下与任何测试菌株孵育1小时后，从未加热或热灭活血清中回收的微生物数量之间没有显著差异。以未加热的正常人血清作为补体来源，将阴道加德纳菌悬浮液在热灭活的同源小鼠抗血清中于37℃孵育1小时，其活力并不比使用热灭活人血清的对照混合物低。相比之下，在热灭活的同源小鼠抗血清中与未加热的正常人血清一起孵育的一株血清抗性淋病奈瑟菌的活力明显低于对照。因此，阴道加德纳菌似乎对正常血清和免疫血清的杀菌活性均具有抗性。
