Farahani Amirhossein, Zarei-Hanzaki Abbas, Abedi Hamid Reza, Tayebi Lobat, Mostafavi Ebrahim
Hot Deformation & Thermomechanical Processing Laboratory of High Performance Engineering Materials, School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran 11155-4563, Iran.
School of Metallurgy & Materials Engineering, Iran University of Science and Technology (IUST), Tehran 16846-13114, Iran.
J Funct Biomater. 2021 Dec 8;12(4):71. doi: 10.3390/jfb12040071.
Polylactide acid (PLA), as an FDA-approved biomaterial, has been widely applied due to its unique merits, such as its biocompatibility, biodegradability, and piezoelectricity. Numerous utilizations, including sensors, actuators, and bio-application-its most exciting application to promote cell migration, differentiation, growth, and protein-surface interaction-originate from the piezoelectricity effect. Since PLA exhibits piezoelectricity in both crystalline structure and an amorphous state, it is crucial to study it closely to understand the source of such a phenomenon. In this respect, in the current study, we first reviewed the methods promoting piezoelectricity. The present work is a comprehensive review that was conducted to promote the low piezoelectric constant of PLA in numerous procedures. In this respect, its chemistry and structural origins have been explored in detail. Combining any other variables to induce a specific application or to improve any PLA barriers, namely, its hydrophobicity, poor electrical conductivity, or the tuning of its mechanical properties, especially in the application of cardiovascular tissue engineering, is also discussed wherever relevant.
聚乳酸（PLA）作为一种经美国食品药品监督管理局（FDA）批准的生物材料，因其独特的优点，如生物相容性、生物可降解性和压电性，而得到广泛应用。包括传感器、致动器以及生物应用（其最令人兴奋的应用是促进细胞迁移、分化、生长和蛋白质-表面相互作用）在内的众多用途都源于压电效应。由于PLA在晶体结构和非晶态下均表现出压电性，因此深入研究以了解这种现象的来源至关重要。在这方面，在当前的研究中，我们首先回顾了促进压电性的方法。目前的工作是一项全面的综述，旨在提高PLA在众多过程中的低压电常数。在这方面，已经详细探讨了其化学和结构起源。在相关的地方，还讨论了结合任何其他变量以诱导特定应用或改善PLA的任何障碍，即其疏水性、低导电性或调节其机械性能，特别是在心血管组织工程应用中。
