Laboratory of Bacteriology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.
Front Cell Infect Microbiol. 2022 Feb 10;12:828784. doi: 10.3389/fcimb.2022.828784. eCollection 2022.
is a zoonotic pathogen responsible for the human disease Q fever. While an inactivated whole cell vaccine exists for this disease, its widespread use is precluded by a post vaccination hypersensitivity response. Efforts for the development of an improved Q fever vaccine are intricately connected to the availability of appropriate animal models of human disease. Accordingly, small mammals and non-human primates have been utilized for vaccine-challenge and post vaccination hypersensitivity modeling. Here, we review the animal models historically utilized in Q fever vaccine development, describe recent advances in this area, discuss the limitations and strengths of these models, and summarize the needs and criteria for future modeling efforts. In summary, while many useful models for Q fever vaccine development exist, there remains room for growth and expansion of these models which will in turn increase our understanding of host interactions.
它是一种人畜共患病病原体，可导致人类疾病 Q 热。虽然已经有针对这种疾病的灭活全细胞疫苗，但由于接种后过敏反应，其广泛使用受到限制。为开发改良的 Q 热疫苗所做的努力与适当的人类疾病动物模型的可用性密切相关。因此，小型哺乳动物和非人类灵长类动物已被用于疫苗接种挑战和接种后过敏反应建模。在这里，我们回顾了历史上用于 Q 热疫苗开发的动物模型，描述了该领域的最新进展，讨论了这些模型的局限性和优势，并总结了未来建模工作的需求和标准。总之，虽然存在许多用于 Q 热疫苗开发的有用模型，但这些模型仍有发展和扩展的空间，这将有助于我们进一步了解宿主的相互作用。
