采用比浊法对部分抗真菌药物针对白色念珠菌ATCC 10231的活性进行体外研究。
In vitro studies of activities of some antifungal agents against Candida albicans ATCC 10231 by the turbidimetric method.
作者信息
Blanco M T, Pérez-Giraldo C, Blanco J, Morán F J, Hurtado C, Gómez-García A C
机构信息
Department of Microbiology, Faculty of Medicine, University of Extremadura, Badajoz, Spain.
出版信息
Antimicrob Agents Chemother. 1992 Apr;36(4):898-901. doi: 10.1128/AAC.36.4.898.
Abstract
Different criteria (the drug concentration which inhibited 50% of growth [IC1/2], the lowest drug concentration at which growth was just less than 30% of that in a positive control well [IC30], the visual inhibitory concentration [ICv], and the minimum fungicidal concentration [MFC]) were applied to study the effects of some antifungal agents against Candida albicans. Amphotericin B, flucytosine, and bifonazole produced total growth inhibition. Clotrimazole, itraconazole, ketoconazole, and miconazole produced partial growth inhibition. The values of IC1/2 and IC30 were similar for all agents and avoided the problems of partial inhibition; the values of ICv and MFC were higher than those of IC1/2 and IC30.
摘要
采用不同标准（抑制50%生长的药物浓度[IC1/2]、生长刚低于阳性对照孔中生长30%时的最低药物浓度[IC30]、视觉抑制浓度[ICv]和最小杀菌浓度[MFC]）研究了一些抗真菌药物对白色念珠菌的作用。两性霉素B、氟胞嘧啶和联苯苄唑产生完全生长抑制。克霉唑、伊曲康唑、酮康唑和咪康唑产生部分生长抑制。所有药物的IC1/2和IC30值相似，避免了部分抑制的问题；ICv和MFC值高于IC1/2和IC30值。
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