Onofrj Valeria, Chiarelli Antonio Maria, Wise Richard, Colosimo Cesare, Caulo Massimo
Department of Medical Imaging, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Department of Radiology and Neuroradiology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Via della Pineta Sacchetti, 217, 00168, Rome, Italy.
Brain Struct Funct. 2022 Jun;227(5):1843-1856. doi: 10.1007/s00429-022-02477-y. Epub 2022 Mar 14.
The salience network (SN), ventral attention network (VAN), dorsal attention network (DAN) and default mode network (DMN) have shown significant interactions and overlapping functions in bottom-up and top-down mechanisms of attention. In the present study, we tested if the SN, VAN, DAN and DMN connectivity can infer the gestational age (GA) at birth in a study group of 88 healthy neonates, scanned at 40 weeks of post-menstrual age, and with GA at birth ranging from 28 to 40 weeks. We also ascertained whether the connectivity within each of the SN, VAN, DAN and DMN was able to infer the average functional connectivity of the others. The ability to infer GA at birth or another network's connectivity was evaluated using a multivariate data-driven framework. The VAN, DAN and the DMN inferred the GA at birth (p < 0.05). The SN, DMN and VAN were able to infer the average connectivity of the other networks (p < 0.05). Mediation analysis between VAN's and DAN's inference on GA at birth found reciprocal transmittance of change with GA at birth of VAN's and DAN's connectivity (p < 0.05). Our findings suggest that the VAN has a prominent role in bottom-up salience detection in early infancy and that the role of the VAN and the SN may overlap in the bottom-up control of attention.
突显网络（SN）、腹侧注意网络（VAN）、背侧注意网络（DAN）和默认模式网络（DMN）在自下而上和自上而下的注意机制中表现出显著的相互作用和重叠功能。在本研究中，我们对88名健康新生儿的研究组进行了测试，这些新生儿在孕龄40周时进行扫描，出生时的孕龄范围为28至40周，以检验SN、VAN、DAN和DMN的连通性是否能够推断出生时的孕龄（GA）。我们还确定了SN、VAN、DAN和DMN各自内部的连通性是否能够推断其他网络的平均功能连通性。使用多变量数据驱动框架评估推断出生时GA或其他网络连通性的能力。VAN、DAN和DMN能够推断出生时的GA（p < 0.05）。SN、DMN和VAN能够推断其他网络的平均连通性（p < 0.05）。对VAN和DAN关于出生时GA的推断进行中介分析发现，VAN和DAN连通性随出生时GA的变化存在相互传递性（p < 0.05）。我们的研究结果表明，VAN在婴儿早期的自下而上突显检测中起重要作用，并且VAN和SN在自下而上的注意控制中的作用可能重叠。
