Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Nutrients. 2022 Mar 28;14(7):1410. doi: 10.3390/nu14071410.
Chrononutrition is an emerging branch of chronobiology focusing on the profound interactions between biological rhythms and metabolism. This framework suggests that, just like all biological processes, even nutrition follows a circadian pattern. Recent findings elucidated the metabolic roles of circadian clocks in the regulation of both hormone release and the daily feeding-fasting cycle. Apart from serving as energy fuel, ketone bodies play pivotal roles as signaling mediators and drivers of gene transcription, promoting food anticipation and loss of appetite. Herein we provide a comprehensive review of the literature on the effects of the ketogenic diets on biological processes that follow circadian rhythms, among them appetite, sleep, and endocrine function.
时间营养是时间生物学的一个新兴分支，专注于生物节律和新陈代谢之间的深刻相互作用。该框架表明，就像所有的生物过程一样，即使是营养也遵循昼夜节律模式。最近的研究结果阐明了生物钟在激素释放和每日进食-禁食周期调节中的代谢作用。除了作为能量燃料外，酮体还作为信号介质和基因转录的驱动因素发挥关键作用，促进食物预期和食欲下降。本文综述了关于生酮饮食对遵循昼夜节律的生物过程（包括食欲、睡眠和内分泌功能）的影响的文献。
