Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas-UNICAMP, Paulínia, SP, 13148-218, Brazil.
Postgraduate Program in Dentistry, Piracicaba Dental School (FOP), University of Campinas, Piracicaba, SP, 13414-903, Brazil.
Inflammopharmacology. 2022 Dec;30(6):2127-2137. doi: 10.1007/s10787-022-00989-x. Epub 2022 Apr 22.
Found in humid regions and waterways and popularly used to treat gastrointestinal problems among other applications, the present study evaluated the M. aquatica essential oil (OEMa) as a therapeutic alternative to treat gastrointestinal disorders. Produced by steam distillation, chemical composition of OEMa was determined by GC-MS analysis. The ethanol-induced ulcer and the dose-repeated acetylsalicylic acid (ASA)-induced gastrointestinal lesions models in rats evaluated, respectively, the prophylactic and curative effects of EOMa on peptic ulcers. The EOMa's effect on gastric secretion, gastric mucus and gastrointestinal motility were evaluated in in vivo models. The curative effect of EOMa on acute colitis was evaluated using the DSS-induced colitis model in mice. Obtained in 0.17% yield (w/w), with carvone (54.82 ± 1.39 g/100 g oil) as the main constituent, EOMa (at 75 mg/kg) showed potent gastroprotective effect (> 90%) mediated by non-protein sulfhydryl compounds (NPSH) and nitric oxide (NO) modulation alongside reduction in gastric secretion volume and total acidity. EOMa did not affect gastric mucus production and gastrointestinal motility. In dose-repeated ASA-induced gastrointestinal lesions model, EOMa (at 25 mg/kg) promoted the inflammatory process resolution both in gastric and duodenal walls by modulating NPSH, NO and myeloperoxidase levels. Despite delaying in 2 days the clinical symptoms worsening, EOMa (at 25 mg/kg) was not able to protect colon tissues from DSS-induced acute colitis as evidenced by macroscopic, biochemical, and histopathological parameters. This is the first report of Mentha aquatica essential oil as a promising herbal medicine for peptic ulcers treatment together with an adjuvant effect in IBD.
发现于潮湿地区和水道中，常用于治疗胃肠道问题等，本研究评估了水薄荷精油（OEMa）作为治疗胃肠道疾病的治疗选择。通过水蒸气蒸馏生产，通过 GC-MS 分析确定 OEMa 的化学成分。评估了乙醇诱导的溃疡和剂量重复的乙酰水杨酸（ASA）诱导的大鼠胃肠道损伤模型，分别评估了 EOMa 对消化性溃疡的预防和治疗作用。在体内模型中评估了 EOMa 对胃分泌、胃粘液和胃肠道动力的影响。通过 DSS 诱导的结肠炎模型评估了 EOMa 对急性结肠炎的治疗作用。以水薄荷为原料，采用水蒸气蒸馏法提取精油，得率为 0.17%（w/w），以蒈酮（54.82±1.39 g/100 g 油）为主要成分，EOMa（75 mg/kg）表现出强大的胃保护作用（>90%），通过非蛋白巯基化合物（NPSH）和一氧化氮（NO）调节，同时减少胃分泌量和总酸度。EOMa 不影响胃粘液的产生和胃肠道的动力。在剂量重复的 ASA 诱导的胃肠道损伤模型中，EOMa（25 mg/kg）通过调节 NPSH、NO 和髓过氧化物酶水平，促进胃和十二指肠壁的炎症过程的缓解。尽管 EOMa（25 mg/kg）延迟了 2 天临床症状的恶化，但未能保护结肠组织免受 DSS 诱导的急性结肠炎，这从宏观、生化和组织病理学参数得到了证实。这是首次报道水薄荷精油作为治疗消化性溃疡的有前途的草药，以及对 IBD 的辅助作用。
