Gupta Ruby, Tomar Ruchi, Chakraverty Suvankar, Sharma Deepika
Institute of Nano Science and Technology Knowledge City, Phase 81 Mohali-140306 Punjab India
RSC Adv. 2021 May 7;11(28):16942-16954. doi: 10.1039/d1ra02376d. eCollection 2021 May 6.
Magnetic hyperthermia-based cancer therapy mediated by magnetic nanomaterials is a promising antitumoral nanotherapy, owning to its power to generate heat under the application of an alternating magnetic field. However, although the ultimate targets of these treatments, the heating potential and its relation with the magnetic behavior of the employed magnetic nanomaterials are rarely studied. Here we provide a bridge between the heating potential and magnetic properties such as anisotropy energy constant and saturation magnetization of the nano-magnets by simultaneous investigation of both hyperthermia and magnetism under a controlled set of variables given by response surface methodology. In the study, we have simultaneously investigated the effect of various synthesis parameters like cation ratio, reaction temperature and time on the magnetic response and heat generation of manganese-doped ferrite nanomaterials synthesized by a simple hydrothermal route. The optimum generation of heat and magnetization is obtained at a cationic ratio of approximately 42 at a temperature of 100 °C for a time period of 4 h. The optimized nanomaterial was then evaluated for magnetic hyperthermia application for cancer therapy against glioblastoma in terms of cell viability, effect on cellular cytoskeleton and morphological alterations. Furthermore, the correlation between the magnetic properties of the synthesized nanomaterial with its hyperthermia output was also established using .. variable where , and are the anisotropy energy constant, volume, and saturation magnetization of the nanomaterial respectively. It was found that the intensity of heat generation decreases with an increase in .. value, beyond 950 J emu g.
基于磁性纳米材料介导的磁热疗癌症治疗是一种很有前景的抗肿瘤纳米疗法，这得益于其在交变磁场作用下产生热量的能力。然而，尽管这些治疗的最终目标是这样，但所使用的磁性纳米材料的发热潜力及其与磁行为的关系却很少被研究。在这里，我们通过响应面法在一组可控变量下同时研究热疗和磁性，在纳米磁体的发热潜力与诸如各向异性能量常数和饱和磁化强度等磁性特性之间架起了一座桥梁。在这项研究中，我们同时研究了各种合成参数，如阳离子比例、反应温度和时间，对通过简单水热法合成的锰掺杂铁氧体纳米材料的磁响应和发热的影响。在阳离子比例约为42、温度为100°C、时间为4小时的条件下，获得了最佳的热生成和磁化效果。然后，对优化后的纳米材料进行了磁热疗应用评估，以治疗胶质母细胞瘤，评估内容包括细胞活力、对细胞骨架的影响和形态学改变。此外，还利用……建立了合成纳米材料的磁性与其热疗输出之间的相关性，其中……变量中，……、……和……分别是纳米材料的各向异性能量常数、体积和饱和磁化强度。结果发现，当……值超过950 J emu g时，发热强度随……值的增加而降低。
