Miller J H, Coulondre C, Farabaugh P J
Nature. 1978 Aug 24;274(5673):770-5. doi: 10.1038/274770a0.
Nonsense mutations derived from 90 different codons in the lacI gene of Escherichia coli have been correlated with the I gene nucleotide sequence. In over 80 cases the specific codon which generates the nonsense mutation can be identified. The sequence shows that 14-16 sites arise through tandem double base changes.
大肠杆菌lacI基因中源自90个不同密码子的无义突变已与I基因核苷酸序列相关联。在80多个案例中，可以确定产生无义突变的特定密码子。序列显示，14 - 16个位点是通过串联双碱基变化产生的。
