Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100910, P. R. China.
College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Sci Adv. 2022 Jun 24;8(25):eabo1458. doi: 10.1126/sciadv.abo1458. Epub 2022 Jun 22.
Living materials are worked as an inside collaborative system that could naturally respond to changing environmental conditions. The regulation of bioelectronic processes in living materials could be effective for collecting biological signals and detecting biomarkers. Here, we constructed a living material with conjugated polymers poly[3-(3'-,,-triethylamino-1'-propyloxy)-4-methyl-2,5-thiophene chloride] (PMNT) and MR-1 biofilm. In addition, the living material was integrated as a flexible bioelectronic device for lactate detection in physiological fluids (sweat, urine, and plasma). Owing to the electroconductivity of conjugated polymers, PMNT could optimize the bioelectronic process in the living material. The collected electrical signal could be wirelessly transferred to a portable smartphone for reading and analyzing. Because lactate is also a biomarker for cancer treatment, the flexible bioelectronic device was further used to detect and count the cancer cells. The proof of the bioelectronic device using conductive polymer-based living material exhibits promising applications in the next-generation personal health monitoring systems.
活体材料被用作内部协作系统，可以自然响应不断变化的环境条件。活体材料中生物电子过程的调节可以有效地收集生物信号和检测生物标志物。在这里，我们构建了一种由共轭聚合物聚[3-(3'-,,-三乙氨基-1'-丙氧基)-4-甲基-2,5-噻吩氯化物] (PMNT) 和 MR-1 生物膜组成的活体材料。此外，该活体材料被集成到一个灵活的生物电子设备中，用于检测生理液（汗液、尿液和血浆）中的乳酸。由于共轭聚合物的导电性，PMNT 可以优化活体材料中的生物电子过程。收集到的电信号可以通过无线方式传输到便携式智能手机进行读取和分析。由于乳酸也是癌症治疗的生物标志物，因此该柔性生物电子设备还可用于检测和计数癌细胞。使用基于导电聚合物的活体材料的生物电子设备的证明展示了在下一代个人健康监测系统中的应用前景。
