Jiang Yulin, Shi Kun, Zhou Luonan, He Miaomiao, Zhu Ce, Wang Jingcheng, Li Jianhua, Li Yubao, Liu Limin, Sun Dan, Feng Ganjun, Yi Yong, Zhang Li
Analytical and Testing Center, Department of Orthopedic Surgery and Orthopedic Research Institute, Sichuan University, Chengdu, 610065, China.
School of Materials Science and Engineering, Southwest University of Science and Technology, Mianyang, 621010, China.
Bioact Mater. 2022 Jun 27;20:528-538. doi: 10.1016/j.bioactmat.2022.06.002. eCollection 2023 Feb.
In this study, a novel artificial intervertebral disc implant with modified "Bucklicrystal" structure was designed and 3D printed using thermoplastic polyurethane. The new implant has a unique auxetic structure with building blocks joined "face-to-face". The accompanied negative Poisson's ratio enables its excellent energy absorption and stability under compression. The deformation and load distribution behavior of the implant under various loading conditions (bending, torsion, extension and flexion) has been thoroughly evaluated through finite element method. Results show that, compared to natural intervertebral disc and conventional 3D implant, our new implant exhibits more effective stress transfer and attenuation under practical loading conditions. The implant's ability to contract laterally under compression can be potentially used to alleviate the symptoms of lumbar disc herniation. Finally, the biocompatibility of the implant was assessed and its ability to restore the physiological function of the disc segment was validated using an animal model.
在本研究中，设计了一种具有改良“Bucklicrystal”结构的新型人工椎间盘植入物，并使用热塑性聚氨酯进行3D打印。这种新型植入物具有独特的负泊松比结构，其构建块“面对面”连接。伴随的负泊松比使其在压缩下具有出色的能量吸收和稳定性。通过有限元方法对植入物在各种加载条件（弯曲、扭转、拉伸和屈曲）下的变形和载荷分布行为进行了全面评估。结果表明，与天然椎间盘和传统3D植入物相比，我们的新型植入物在实际加载条件下表现出更有效的应力传递和衰减。植入物在压缩下横向收缩的能力可能用于缓解腰椎间盘突出症的症状。最后，评估了植入物的生物相容性，并使用动物模型验证了其恢复椎间盘节段生理功能的能力。
