Zamruddin Nur Masyithah, Herman Herman, Rijai Laode, Hasanah Aliya Nur
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung Sumedang KM 21, Sumedang 45363, Indonesia.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mulawarman University, Gunung Kelua 75119, Indonesia.
Polymers (Basel). 2022 Jul 25;14(15):3008. doi: 10.3390/polym14153008.
During the last few years, separation techniques using molecular imprinting polymers (MIPs) have been developed, making certain improvements using magnetic properties. Compared to MIP, Magnetic molecularly imprinted polymers (MMIPs) have high selectivity in sample pre-treatment and allow for fast and easy isolation of the target analyte. Its magnetic properties and good extraction performance depend on the MMIP synthesis step, which consists of 4 steps, namely magnetite manufacture, magnetic coating using modified components, polymerization and template desorption. This review discusses the factors that will affect the performance of MMIP as a selective sorbent at each stage. MMIP, using FeO as a magnetite core, showed strong superparamagnetism; it was prepared using the co-precipitation method using FeCl·6HO and FeCl·HO to obtain high magnetic properties, using NHOH solution added for higher crystallinity. In magnetite synthesis, the use of a higher temperature and reaction time will result in a larger nanoparticle size and high magnetization saturation, while a higher pH value will result in a smaller particle size. In the modification step, the use of high amounts of oleic acid results in smaller nanoparticles; furthermore, determining the correct molar ratio between FeCl and the shielding agent will also result in smaller particles. The next factor is that the proper ratio of functional monomer, cross-linker and solvent will improve printing efficiency. Thus, it will produce MMIP with high selectivity in sample pre-treatment.
在过去几年中，已经开发出了使用分子印迹聚合物（MIP）的分离技术，并利用磁性进行了一些改进。与MIP相比，磁性分子印迹聚合物（MMIP）在样品预处理中具有高选择性，并且能够快速、轻松地分离目标分析物。其磁性和良好的萃取性能取决于MMIP的合成步骤，该步骤包括4个步骤，即磁铁矿制备、使用改性成分进行磁性包覆、聚合和模板解吸。本文综述了在每个阶段会影响MMIP作为选择性吸附剂性能的因素。以FeO作为磁铁矿核心的MMIP表现出强超顺磁性；它是通过共沉淀法制备的，使用FeCl·6H₂O和FeCl·H₂O以获得高磁性，加入NH₄OH溶液以提高结晶度。在磁铁矿合成中，使用较高的温度和反应时间会导致更大的纳米颗粒尺寸和高磁化饱和度，而较高的pH值会导致更小的颗粒尺寸。在改性步骤中，使用大量油酸会导致纳米颗粒更小；此外，确定FeCl与屏蔽剂之间正确的摩尔比也会导致颗粒更小。下一个因素是功能单体、交联剂和溶剂的适当比例将提高印迹效率。因此，它将产生在样品预处理中具有高选择性的MMIP。
