Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", via Solaroli 17, 28100, Novara, Italy.
Translational Medicine, Dipartimento Attività Integrate Ricerca e Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Aging Clin Exp Res. 2022 Nov;34(11):2659-2674. doi: 10.1007/s40520-022-02203-y. Epub 2022 Aug 3.
To date, the mitochondrial function has been related to several pathways involved in the cellular aging process. Dietary supplements might have reciprocal and multilevel interactions with mitochondria network; however, no systematic review assessed the role of different nutraceuticals in mitochondria modification of healthy older adults.
To assess the effects of different dietary supplements on mitochondria modifications in older adults.
On February 22, 2022, PubMed, Scopus, Web of Science, and Cochrane were systematically searched from inception for randomized controlled trials (RCTs). According to PICO model, we considered healthy older adults as participants, nutraceutical treatment as intervention, any treatment as comparator, mitochondrial modifications as outcome. Jadad scale was used for the quality assessment.
Altogether, 8489 records were identified and screened until 6 studies were included. A total of 201 healthy older adults were included in the systematic review (mean age ranged from 67.0 ± 1.0 years to 76.0 ± 5.6 years). The dietary supplements assessed were sodium nitrite, N-3 polyunsaturated fatty acids, hydrogen-rich water, nicotinamide riboside, urolithin A, and whey protein powder. Positive effects were reported in terms of mitochondrial oxidative and antioxidant capacity, volume, bioenergetic capacity, and mitochondrial transcriptome based on the nutritional supplements. The quality assessment underlined that all the studies included were of good quality.
Although dietary supplements might provide positive effects on mitochondria modifications, few studies are currently available in this field.
Further studies are needed to better elucidate the reciprocal and multilevel interactions between nutraceuticals, mitochondria, and environmental stressors in healthy older adults.
迄今为止，线粒体功能已与细胞衰老过程中涉及的几种途径相关联。膳食补充剂可能与线粒体网络存在相互的多层次相互作用；然而，尚无系统评价评估不同营养保健品对健康老年人线粒体改变的作用。
评估不同膳食补充剂对老年人线粒体改变的影响。
2022 年 2 月 22 日，系统检索了 PubMed、Scopus、Web of Science 和 Cochrane 数据库，以获取从建库起的随机对照试验（RCT）。根据 PICO 模型，我们将健康老年人视为参与者，营养保健品治疗为干预措施，任何治疗为对照，线粒体改变为结局。采用 Jadad 量表进行质量评估。
共识别并筛选了 8489 条记录，最终纳入了 6 项研究。共有 201 名健康老年人纳入系统评价（平均年龄范围为 67.0±1.0 岁至 76.0±5.6 岁）。评估的膳食补充剂包括亚硝酸钠、N-3 多不饱和脂肪酸、富氢水、烟酰胺核苷、尿石素 A 和乳清蛋白粉。基于营养补充剂，报告了线粒体氧化和抗氧化能力、体积、生物能量能力和线粒体转录组的积极影响。质量评估强调，所有纳入的研究均为高质量研究。
尽管膳食补充剂可能对线粒体改变产生积极影响，但目前该领域的研究较少。
需要进一步的研究来更好地阐明营养保健品、线粒体和健康老年人环境应激源之间的相互和多层次相互作用。
