Goel Kapil, Sen Arunima, Goel Parul, Satapathy Prakasini, Jain Lovely, Vij Jatina, Patro Binod Kumar, Kar Sitanshu Sekhar, Chakrapani Venkatesan, Singh Ritesh, Pala Star, Sankhe Lalit, Modi Bhavesh, Bali Surya, Rustagi Neeti, Nadda Anuradha, Rajagopal Vineeth, Kiran Tanvi, Aggarwal Arun Kumar, Gupta Madhu, Padhi Bijaya Kumar
Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Department of Biochemistry, Shri Atal Bihari Vajpayee Government Medical College Chhainsa, Faridabad, Haryana, India.
Clin Epidemiol Glob Health. 2022 Sep-Oct;17:101113. doi: 10.1016/j.cegh.2022.101113. Epub 2022 Jul 30.
Vaccine hesitancy is of considerable concern as it threatens the great potential of a vaccine against COVID-19. This study aims to determine factors associated with community health workers' willingness to participate in clinical trials of COVID-19 vaccine, and their vaccination intention, in India.
A cross-sectional study was conducted among 377 community health workers using self-administered anonymous questionnaire during the lockdown periods in India. Participant's socio-demographics, willingness-to-participate in COVID-19 vaccine trials, intention to accept COVID-19 vaccine were recorded in a Likert scale. Data were analysed descriptively, and a multivariate logistic regression model was used to investigate factors associated with willingness to participate and accept the vaccine.
Among 377 CHWs, 70 (19%) intended to participate in COVID-19 vaccine trial, 151 (40%) responded positively regarding their intention to get vaccinated. Those with knowledge on development of COVID-19 vaccine [aOR 3.05 (95% CI: 1.18-7.88), p = 0.021], and men [aOR 3.69 (95% CI: 1.51-8.97), p = 0.004] were more willing to participate in clinical-trial, while an undergraduate degree, and trust in domestic vaccines were identified as deterrents for the same. Perceiving COVID-19 as risk [aOR 2.31 (95% CI: 1.24-4.31), p = 0.009], and male gender [aOR 2.39 (95% CI: 1.17-4.88), p = 0.017] were factors associated with intention to get vaccinated. Respondents who had knowledge about COVID-19 virus were less likely to uptake the hypothetical vaccine [aOR 0.32 (95% CI: 0.12-0.88), p = 0.027].
Increasing knowledge regarding COVID-19 is not enough to improve vaccine acceptance rates. Targeted interventions addressing socio-demographic determinants related to COVID-19 vaccination should help improve acceptance.
疫苗犹豫令人深感担忧，因为它威胁到新冠疫苗的巨大潜力。本研究旨在确定印度社区卫生工作者参与新冠疫苗临床试验的意愿及其接种意愿的相关因素。
在印度封锁期间，对377名社区卫生工作者进行了一项横断面研究，采用自行填写的匿名问卷。参与者的社会人口统计学特征、参与新冠疫苗试验的意愿、接受新冠疫苗的意愿采用李克特量表记录。对数据进行描述性分析，并使用多变量逻辑回归模型研究与参与意愿和接受疫苗相关的因素。
在377名社区卫生工作者中，70人（19%）打算参与新冠疫苗试验，151人（40%）对其接种意愿给出了肯定答复。了解新冠疫苗研发情况的人 [调整后比值比3.05（95%置信区间：1.18 - 7.88），p = 0.021] 和男性 [调整后比值比3.69（95%置信区间：1.51 - 8.97），p = 0.004] 更愿意参与临床试验，而本科学历和对国产疫苗的信任被确定为参与临床试验的阻碍因素。将新冠视为风险 [调整后比值比2.31（95%置信区间：1.24 - 4.31），p = 0.009] 和男性 [调整后比值比2.39（95%置信区间：1.17 - 4.88），p = 0.017] 是与接种意愿相关的因素。了解新冠病毒的受访者接种假设疫苗的可能性较小 [调整后比值比0.32（95%置信区间：0.12 - 0.88），p = 0.027]。
增加对新冠的了解不足以提高疫苗接种率。针对与新冠疫苗接种相关的社会人口学决定因素的有针对性干预措施应有助于提高接种率。
