Chi Yaqi, Wang Ye, Ji Mengzhen, Li Yanyao, Zhu Hualing, Yan Yujia, Fu Di, Zou Ling, Ren Biao
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Microbiol. 2022 Aug 12;13:955459. doi: 10.3389/fmicb.2022.955459. eCollection 2022.
Oral cavity is an ideal habitat for more than 1,000 species of microorganisms. The diverse oral microbes form biofilms over the hard and soft tissues in the oral cavity, affecting the oral ecological balance and the development of oral diseases, such as caries, apical periodontitis, and periodontitis. Currently, antibiotics are the primary agents against infectious diseases; however, the emergence of drug resistance and the disruption of oral microecology have challenged their applications. The discovery of new antibiotic-independent agents is a promising strategy against biofilm-induced infections. Natural products from traditional medicine have shown potential antibiofilm activities in the oral cavity with high safety, cost-effectiveness, and minimal adverse drug reactions. Aiming to highlight the importance and functions of natural products from traditional medicine against oral biofilms, here we summarized and discussed the antibiofilm effects of natural products targeting at different stages of the biofilm formation process, including adhesion, proliferation, maturation, and dispersion, and their effects on multi-species biofilms. The perspective of antibiofilm agents for oral infectious diseases to restore the balance of oral microecology is also discussed.
口腔是1000多种微生物的理想栖息地。多样的口腔微生物在口腔的软硬组织上形成生物膜，影响口腔生态平衡以及龋齿、根尖周炎和牙周炎等口腔疾病的发展。目前，抗生素是治疗传染病的主要药物；然而，耐药性的出现和口腔微生态的破坏对其应用提出了挑战。发现新的非抗生素类药物是对抗生物膜引起的感染的一种有前景的策略。传统医学中的天然产物在口腔中显示出潜在的抗生物膜活性，具有高安全性、成本效益和最小的药物不良反应。为了突出传统医学天然产物对口腔生物膜的重要性和作用，我们在此总结并讨论了天然产物针对生物膜形成过程不同阶段（包括黏附、增殖、成熟和分散）的抗生物膜作用，以及它们对多物种生物膜的影响。还讨论了用于口腔传染病的抗生物膜药物恢复口腔微生态平衡的前景。
