猴痘病毒：过去与现在。
Monkeypox virus: past and present.
机构信息
NHC Key Laboratory of Medical Virology and Viral Disease, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, 155 Changbai Road, ChangPing District, Beijing, 102206, China.
出版信息
World J Pediatr. 2023 Mar;19(3):224-230. doi: 10.1007/s12519-022-00618-1. Epub 2022 Oct 10.
BACKGROUND
The objective of this paper is to analyze the current status of monkeypox worldwide. In the face of this public health threat, our purpose is to elucidate the clinical characteristics and epidemiology of monkeypox, the developmental progress of monkeypox-related drugs and the vaccines available.
DATA SOURCES
The literature review was performed in databases including PubMed, Science Direct and Google Scholar up to July 2022.
RESULTS
Since May 2022, the World Health Organization has reported more than 45,000 confirmed cases from 92 nonendemic countries, including nine deaths. Although some women and children have been infected so far, most cases have occurred among men who have sex with other men, especially those with multiple sexual partners or anonymous sex.
CONCLUSIONS
Pediatric monkeypox infection has been associated with a higher likelihood of severe illness and mortality than in adults. Severe monkeypox illness in pediatrics often requires adjunctive antiviral therapy. It is crucial for all countries to establish sound monitoring and testing systems and be prepared with emergency preparedness.
背景
本文旨在分析全球猴痘的现状。面对这一公共卫生威胁，我们旨在阐明猴痘的临床特征和流行病学、猴痘相关药物的研发进展以及现有的疫苗。
资料来源
文献综述在包括 PubMed、Science Direct 和 Google Scholar 在内的数据库中进行，截至 2022 年 7 月。
结果
自 2022 年 5 月以来，世界卫生组织已报告来自 92 个非流行国家的超过 45000 例确诊病例，包括 9 例死亡。尽管迄今为止已有一些妇女和儿童感染，但大多数病例发生在与其他男性发生性关系的男性中，特别是那些有多个性伴侣或匿名性行为的男性。
结论
儿科猴痘感染与成人相比，更有可能导致严重疾病和死亡。儿科严重猴痘病常需要辅助抗病毒治疗。所有国家建立健全的监测和检测系统并做好应急准备至关重要。
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