益生菌与镁联合补充对肥胖且情绪低落个体的情绪、认知、肠道屏障功能及炎症的影响：一项随机、双盲、安慰剂对照临床试验
Effects of probiotic and magnesium co-supplementation on mood, cognition, intestinal barrier function and inflammation in individuals with obesity and depressed mood: A randomized, double-blind placebo-controlled clinical trial.
作者信息
Mahboobi Sepideh, Ghasvarian Marzieh, Ghaem Haleh, Alipour Hamzeh, Alipour Shohreh, Eftekhari Mohammad Hassan
机构信息
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Epidemiology, Non-communicable Diseases Research Center, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Front Nutr. 2022 Sep 28;9:1018357. doi: 10.3389/fnut.2022.1018357. eCollection 2022.
BACKGROUND
The co-occurrence of obesity and mood impairments named as "metabolic mood syndrome" (MMS) is often neglected in the obesity management. This study aimed to evaluate effects of Probio-Tec BG-VCap-6.5 and magnesium co-supplementation on mood, cognition, intestinal barrier function and serum C reactive protein (CRP) levels in participants with obesity and depressed mood.
DESIGN
Seventy-four eligible participants were randomly allocated to either Probio-TecBG-VCap-6.5 [containing (LGG) and subsp. (BB-12)] + Magnesium chloride or placebo for 9 weeks. Sociodemographic data were collected in the beginning. Anthropometric, dietary and physical activity (PA) assessments were carried out. Beck Depression Inventory-II (BDI-II) and Montreal Cognitive Assessment (MoCA) scores were assessed through validated questionnaires. Fasting plasma zonulin, lipopolysaccharide (LPS) and (CRP) were measured by ELIZA kits.
RESULTS
Of seventy-four participants (mean age 37.51 ± 8.10), 52 completed the study. Changes in serum LPS and zonulin were not different significantly between groups (-3.04 ± 44.75 ng/dl, 0.11 ± 5.13, ng/dl, > 0.05 for LPS and 1.40 ± 48.78 ng/dl, -0.17 ± 6.60, > 0.05 for zonulin, respectively). CRP levels reduced significantly in intervention group compared to placebo [-474.75 (-1,300.00, -125.00) mg/l vs. 175.20 (-957.75, 1,683.25) mg/l, = 0.016]. Changes in BDI-II and MoCA scores were not significantly different between intervention (-7.13 ± 5.67, 1.20 ± 2.16, respectively) and placebo (-5.42 ± 6.71, 1.94 ± 1.86, respectively) groups ( > 0.05).
CONCLUSION
Nine weeks of probiotic and magnesium co-supplementation resulted in decreased CRP levels as an indicator of inflammatory state with no significant effects on mood, cognition and intestinal integrity in individuals with obesity and depressed mood.
背景
肥胖与情绪障碍同时出现，即“代谢性情绪综合征”（MMS），在肥胖管理中常常被忽视。本研究旨在评估联合补充益生菌制剂Probio-Tec BG-VCap-6.5和镁对肥胖且情绪抑郁参与者的情绪、认知、肠道屏障功能及血清C反应蛋白（CRP）水平的影响。
设计
74名符合条件的参与者被随机分为两组，一组服用Probio-Tec BG-VCap-6.5（含鼠李糖乳杆菌GG株和双歧杆菌BB-12株）加氯化镁，另一组服用安慰剂，为期9周。研究开始时收集社会人口学数据。进行人体测量、饮食和身体活动（PA）评估。通过经过验证的问卷评估贝克抑郁量表第二版（BDI-II）和蒙特利尔认知评估（MoCA）得分。采用酶联免疫吸附测定试剂盒检测空腹血浆中连蛋白、脂多糖（LPS）和CRP水平。
结果
74名参与者（平均年龄37.51±8.10岁）中，52人完成了研究。两组之间血清LPS和连蛋白的变化无显著差异（LPS：-3.04±44.75 ng/dl，P>0.05；连蛋白：1.40±48.78 ng/dl，P>0.05）。与安慰剂组相比，干预组的CRP水平显著降低[-474.75（-1300.00，-125.00）mg/l vs. 175.20（-957.75，1683.25）mg/l，P = 0.016]。干预组（分别为-7.13±5.67和1.20±2.16）和安慰剂组（分别为-5.42±6.71和1.94±1.86）之间BDI-II和MoCA得分的变化无显著差异（P>0.05）。
结论
联合补充益生菌和镁9周可使CRP水平降低，作为炎症状态的指标，对肥胖且情绪抑郁个体的情绪、认知和肠道完整性无显著影响。
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