梅毒螺旋体免疫逃逸机制的研究。
Investigation of the immune escape mechanism of Treponema pallidum.
机构信息
Department of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, Hengyang Medical School, The First Affiliated Hospital, University of South China, No. 69, Chuanshan Road, Hengyang City, 421000, Hunan, China.
出版信息
Infection. 2023 Apr;51(2):305-321. doi: 10.1007/s15010-022-01939-z. Epub 2022 Oct 19.
BACKGROUND
Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subspecies pallidum (T. pallidum), which is a public health problem that seriously affects human health worldwide. T. pallidum is characterized by early transmission and immune escape and is therefore termed an "invisible pathogen".
METHODS
This review systematically summarizes the host's innate and adaptive immune responses to T. pallidum infection as well as the escape mechanisms of T. pallidum.
PURPOSE
To lay the foundation for assessing the pathogenic mechanism and the systematic prevention and treatment of syphilis.
CONCLUSION
The immune escape mechanism of T. pallidum plays an important role in its survival. Exploring the occurrence and development of these mechanisms has laid the foundation for the development of syphilis vaccine.
背景
梅毒是一种由苍白密螺旋体亚种苍白密螺旋体（T. pallidum）引起的慢性性传播疾病，是严重影响全球人类健康的公共卫生问题。苍白密螺旋体的特点是早期传播和免疫逃避，因此被称为“隐形病原体”。
方法
本综述系统总结了宿主对苍白密螺旋体感染的固有和适应性免疫反应以及苍白密螺旋体的逃逸机制。
目的
为评估梅毒的致病机制以及梅毒的系统预防和治疗奠定基础。
结论
苍白密螺旋体的免疫逃避机制在其生存中起着重要作用。探讨这些机制的发生和发展为梅毒疫苗的开发奠定了基础。
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