Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education, Southwest Minzu University, Chengdu 610225, China.
Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining 810016, China.
Int J Mol Sci. 2022 Oct 17;23(20):12411. doi: 10.3390/ijms232012411.
Due to its prominent secretory activity, adipose tissue (AT) is now considered a major player in the crosstalk between organs, especially with skeletal muscle. In which, exosomes are effective carriers for the intercellular material transfer of a wide range of molecules that can influence a series of physiological and pathological processes in recipient cells. Considering their underlying roles, the regulatory mechanisms of adipose-secreted exosomes and their cellular crosstalk with skeletal muscle have received great attention in the field. In this review, we describe what is currently known of adipose-secreted exosomes, as well as their applications in skeletal muscle pathophysiology.
由于其显著的分泌活性，脂肪组织 (AT) 现在被认为是器官之间串扰的主要参与者，特别是与骨骼肌之间。其中，外泌体是广泛的分子细胞间物质传递的有效载体，这些分子可以影响受体细胞中的一系列生理和病理过程。鉴于它们的潜在作用，脂肪分泌的外泌体的调节机制及其与骨骼肌的细胞串扰在该领域受到了极大的关注。在这篇综述中，我们描述了目前已知的脂肪分泌的外泌体，以及它们在骨骼肌病理生理学中的应用。
